Chronic pain enhances excitability of corticotropin-releasing factor-expressing neurons in the oval part of the bed nucleus of the stria terminalis

被引：0
作者：
Uchida, Ryoko [1 ]
Mukai, Yasutaka [2 ,5 ,9 ]
Amano, Taiju [1 ]
Sakimura, Kenji [3 ]
Itoi, Keiichi [4 ]
Yamanaka, Akihiro [2 ,6 ,7 ,8 ]
Minami, Masabumi [1 ]
机构：
[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Dept Pharmacol, Sapporo 0600812, Japan
[2] Nagoya Univ, Res Inst Environm Med, Dept Neurosci 2, Nagoya, Aichi 4648601, Japan
[3] Niigata Univ, Brain Res Inst, Dept Anim Model Dev, Niigata 9518585, Japan
[4] Tohoku Fukushi Univ, Dept Nursing, Sendai 9818522, Japan
[5] Hokkaido Univ, Grad Sch Med, Dept Cellular Pharmacol, Sapporo 0608638, Japan
[6] Chinese Inst Brain Res, Beijing 102206, Peoples R China
[7] Keio Univ, Sch Med, Inst Adv Med Res, Div Brain Sci, Shinjuku Ku, Tokyo 1608582, Japan
[8] Natl Inst Nat Sci, Natl Inst Physiol Sci, Okazaki, Aichi 4448585, Japan
[9] Japan Soc Promot Sci, Tokyo 1020083, Japan
来源：
MOLECULAR BRAIN | 2024年 / 17卷 / 01期
基金：
日本学术振兴会;
关键词：
Bed nucleus of the stria terminalis; Chronic pain; Corticotropin-releasing factor; Neuronal excitability; Negative emotion; BEHAVIORS;
D O I：
10.1186/s13041-024-01094-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We previously reported that enhanced corticotropin-releasing factor (CRF) signaling in the bed nucleus of the stria terminalis (BNST) caused the aversive responses during acute pain and suppressed the brain reward system during chronic pain. However, it remains to be examined whether chronic pain alters the excitability of CRF neurons in the BNST. In this study we investigated the chronic pain-induced changes in excitability of CRF-expressing neurons in the oval part of the BNST (ovBNSTCRF neurons) by whole-cell patch-clamp electrophysiology. CRF-Cre; Ai14 mice were used to visualize CRF neurons by tdTomato. Electrophysiological recordings from brain slices prepared from a mouse model of neuropathic pain revealed that rheobase and firing threshold were significantly decreased in the chronic pain group compared with the sham-operated control group. Firing rate of the chronic pain group was higher than that of the control group. These data indicate that chronic pain elevated neuronal excitability of ovBNSTCRF neurons.
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页数：5
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