Synthesis and biological activity of condensed derivatives of thieno[3,2-d]thiazolo(thiazino, thiazepino)[3,2-a]pyrimidines

被引：0

作者：

E. G. Paronikyan

Sh. F. Akopyan

A. S. Noravyan

G. A. Panosyan

G. M. Stepanyan

B. T. Garibdzhanyan

I. A. Dzhagatspanyan

I. M. Nazaryan

A. G. Akopyan

机构：

[1] National Academy of Sciences of Armenia,Mndzhoyan Institute of Fine Organic Chemistry

[2] National Academy of Sciences of Armenia,Molecular Structure Research Center

来源：

Pharmaceutical Chemistry Journal | 2009年 / 43卷

关键词：

pyrano[4′,3′:4,5]pyrido[2,3-; ]thieno[3,2-; ]thiazolo(thiazino, thiazepino)[3,2-; ]pyrimidine; thiazolo(thiazino, thiazepino)[3″,2″:1′,2′]pyrimido[4′,5′:4,5]thieno[2,3-; ]isoquinoline; cyclopenta[4′,3′:4,5]-pyrido[2,3-; ]thieno[3,2-; ]thiazolo(thiazino)[3,2-; ]pyrimidine; 1-amino-2-ethoxycarbonylpyrano[4,3-; ]-thieno[2,3-; ]pyridines and -thieno[2,3-; ]isoquinoline;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Methods for the synthesis of new heterosystems including condensed pyrano[4′,3′:4,5]pyrido[2,3-b]-thieno[3,2-d]thiazolo(thiazino, thiazepino)[3,2-a]pyrimidines, thiazolo(thiazino, thiazepino)[3″,2″:1′,2′]pyrimido[4′,5′:4,5]thieno[2,3-c]isoquinolines, and cyclopenta[4′,3′:4,5]pyrido[2,3-b]thieno[3,2-d]thiazolo(thiazino)[3,2-a]pyrimidines are developed. The synthesis is carried out on the basis of 1-amino-2-ethoxycarbonylpyrano[4,3-d]thieno[2,3-b]pyridines and -thieno[2,3-b]isoquinolines. Antitumor and anticonvulsant properties of the synthesized products have been evaluated. Compounds possessing low toxicity and moderate biological activity are found.

引用

页码：139 / 143

页数：4

共 50 条

[1] Synthesis and biological activity of condensed derivatives of thieno[3,2-d]thiazolo(thiazino, thiazepino)[3,2-a]pyrimidines
Paronikyan, E. G.
Akopyan, Sh. F.
Noravyan, A. S.
Panosyan, G. A.
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