Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches

被引：0
作者：
Yaxian Wang
Xinyang Zhong
Xuefeng He
Zijuan Hu
Huixia Huang
Jiayu Chen
Keji Chen
Senlin Zhao
Ping Wei
Dawei Li
机构：
[1] Fudan University Shanghai Cancer Center,Department of Colorectal Surgery
[2] Shanghai Medical College of Fudan University,Department of Oncology
[3] Cancer Institute,ZJU
[4] The Second Affiliated Hospital,UCLA Joint Center for Medical Education and Research
[5] Zhejiang University School of Medicine,Department of Pathology
[6] Fudan University Shanghai Cancer Center,Institute of Pathology
[7] Cancer Institute,undefined
[8] Fudan University Shanghai Cancer Center,undefined
[9] Fudan University,undefined
来源：
Journal of Experimental & Clinical Cancer Research | / 42卷
关键词：
Colorectal cancer liver metastasis; Premetastatic niche; Immune landscape; Tumour microenvironment; Immunotherapy;
D O I：
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学科分类号：
摘要：
Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy has demonstrated encouraging outcomes in CRC, its benefits are minimal in CRLM. The complex immune landscape of the hepatic tumour microenvironment is essential for the development of a premetastatic niche and for the colonisation and metastasis of CRC cells; thus, an in-depth understanding of these mechanisms can provide effective immunotherapeutic targets for CRLM. This review summarises recent studies on the immune landscape of the tumour microenvironment of CRLM and highlights therapeutic prospects for targeting the suppressive immune microenvironment of CRLM.
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