Mimosine induces apoptosis in the HL60 human tumor cell line

被引：0
作者：
F. Renò
A. Tontini
S. Burattini
S. Papa
E. Falcieri
G. Tarzia
机构：
[1] Università di Ferrara and Centro di Citometria,Istituto di Anatomia Umana
[2] Istituto di Scienze Morfologiche,Istituto di Chimica Farmaceutica
[3] via M. Oddi 23,Istituto di Citomorfologia Normale e Patologica, CNR, c/o Istituti Ortopedici Rizzoli, via di Barbiano 1/10 Bologna
[4] Università di Urbino,undefined
[5] Università di Urbino,undefined
[6] Centro di Citometria,undefined
[7] Istituto di Scienze Morfologiche,undefined
[8] Istituto di Anatomia e Fisiologia,undefined
来源：
Apoptosis | 1999年 / 4卷
关键词：
Apoptosis; cell cycle synchronization; HL60; hypusine; K562; mimosine.;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mimosine, a plant amino acid not found in proteins, has been widely used as a synchronizing agent, blocking the progression of cell cycle on the G1/S phase border. The mechanism by which this block is achieved is still unclear. We report that in HL60 cells the synchronization is related to an increase in apoptosis. Another human tumor cell line, K562, is insensitive to both phenomena thereby demonstrating that apoptosis observed in HL60 is line-specific. We hypothesize that the mimosine-induced apoptosis and alteration of the cell cycle is due to the inhibition of hypusine generation.
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页码：469 / 477
页数：8
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