Effect of Gas Bubbles on the Recovery Efficiency of Paclitaxel from Biomass of Taxus chinensis in Ultrasonic Extraction

被引：0
作者：
Hyo-Jin Jeon
Jin-Hyun Kim
机构：
[1] Kongju National University,Center for Future Sustainable Technology, Department of Chemical Engineering
来源：
Biotechnology and Bioprocess Engineering | 2023年 / 28卷
关键词：
paclitaxel; extraction; cavitation bubble; gas bubble; synergistic effect;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The synergistic effect of introducing both ultrasonic cavitation bubbles and gas bubbles to the extraction of paclitaxel from Taxus chinensis biomass was investigated. The addition of gas bubbles to ultrasonic extraction significantly improved the extraction efficiency, confirming that ultrasonic cavitation bubbles and gas bubbles have a synergistic effect. Furthermore, an ultrasonic power of 250 W and a gas flow rate of 1.750 L/min could recover up to 94% of the paclitaxel from the biomass. In addition, as the ultrasonic power and gas flow rate increased, the extraction rate constant, the effective diffusion coefficient, and the mass transfer coefficient also increased. The efficiency of paclitaxel extraction was improved by the efficient crushing of the biomass facilitated by the synergistic effect of the ultrasonic cavitation bubbles and the gas bubbles.
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页码：545 / 553
页数：8
相关论文
共 75 条
[1]  
Kim H-G(2022)Elucidation of the mechanism and kinetics of ultrasonic extraction of paclitaxel from plant cell cultures of Biotechnol. Bioprocess Eng. 27 668-677
[2]  
Kim J-H(2019)Progress in research on paclitaxel and tumor immunotherapy Cell. Mol. Biol. Lett. 24 40-5051
[3]  
Zhu L(2016)Paclitaxel suppresses collagen-induced arthritis: a reevaluation Am. J. Transl. Res. 8 5044-418
[4]  
Chen L(2018)Comparison of synthetic and natural Taxol extracted from Taxus plant ( Eurasia J. Biosci. 12 413-245
[5]  
Zhao Y(2014)) on growth of ovarian cancer cells under New Biotechnol. 31 242-323
[6]  
Chang Z-F(2020) condition Process Biochem. 99 316-407
[7]  
Li R(2022)Paclitaxel: biosynthesis, production and future prospects Korean J. Chem. Eng. 39 398-118
[8]  
Li Z-G(2022)Cavitation bubble- and gas bubble-induced fractional precipitation of paclitaxel from Biotechnol. Bioprocess Eng. 27 111-23
[9]  
Li X-X(2004)Ultrasound-negative pressure cavitation extraction of paclitaxel from Adv. Biochem. Eng. Biotechnol. 87 1-62
[10]  
Li L(2022)Study of the extraction kinetics and calculation of effective diffusivity and mass transfer coefficient in negative pressure cavitation extraction of paclitaxel from Korean J. Chem. Eng. 39 58-155
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