Roles of MT-ND1 in Cancer

被引：0
作者：
Yi-chun Xu
Jun Su
Jia-jing Zhou
Qing Yuan
Jun-song Han
机构：
[1] Tongji Hospital Affiliated to Tongji University,Department of Pathology, Shanghai Tongji Hospital
[2] Shanghai Biochip Limited Corporation,National Engineering Research Center for Biochip
来源：
Current Medical Science | 2023年 / 43卷
关键词：
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1; cancer; biomarker; mutation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The energy shift toward glycolysis is one of the hallmarks of cancer. Complex I is a vital enzyme complex necessary for oxidative phosphorylation. The mitochondrially encoded NADH: ubiquinone oxidoreductase core subunit 1 (MT-ND1) is the largest subunit coded by mitochondria of complex I. The present study summarizes the structure and biological function of MT-ND1. From databases and literature, the expressions and mutations of MT-ND1 in a variety of cancers have been reviewed. MT-ND1 may be a biomarker for cancer diagnosis and prognosis. It is also a potential target for cancer therapy.
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页码：869 / 878
页数：9
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