The impact of epidermal-growth-factor-receptor mutations in response to lung-cancer therapy

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Jonathan E Dowell
John D Minna
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[1] University of Texas Southwestern Medical Center,Director of Hamon Center for Therapeutic Oncology Research and a Professor in the Departments of Internal Medicine and Pharmacology
[2] Chief of Hematology and Oncology at the Dallas Veterans Affairs Medical Center,undefined
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Non-small-cell lung cancer is the leading cause of cancer death in the US despite advances in therapy. The epidermal-growth-factor receptor has been investigated as a target for therapy using EGFR-specific tyrosine kinase inhibitors. This Viewpoint discusses the implications of the correlation of positive responses seen in patients harboringEGFRmutations.
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