piRNAs and siRNAs collaborate in Caenorhabditis elegans genome defense

被引:0
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作者
Allison C Billi
Mallory A Freeberg
John K Kim
机构
[1] University of Michigan,Life Sciences Institute, Department of Human Genetics
[2] University of Michigan,Department of Human Genetics
[3] University of Michigan,Department of Computational Medicine and Bioinformatics
来源
Genome Biology | / 13卷
关键词
piRNA; siRNA; Piwi; germline; genome surveillance; epigenetics; gene silencing; transposable elements;
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学科分类号
摘要
Caenorhabditis elegans piRNAs promote genome surveillance by triggering siRNA-mediated silencing of nonself DNA in competition with licensing programs that support endogenous gene expression.
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