P2 receptors in macrophage fusion and osteoclast formation

被引：0
|
作者：
Thomas H. Steinberg
Jeffrey F. Hiken
机构：
[1] Washington University School of Medicine,Department of Internal Medicine
[2] Infectious Diseases,undefined
来源：
Purinergic Signalling | 2007年 / 3卷
关键词：
giant cell formation; osteoclast; purinergic receptors;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cells of the mononuclear phagocyte lineage fuse to form multinucleated giant cells and osteoclasts. Several lines of evidence suggest that P2 receptors, in particular P2X7, are involved in this process, although P2X7 is not absolutely required for fusion because P2X7-null mice form multinucleated osteoclasts. Extracellular ATP may be an important regulator of macrophage fusion.
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页码：53 / 57
页数：4
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