NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

被引：0
|
作者：
Louise Hecker
Ragini Vittal
Tamara Jones
Rajesh Jagirdar
Tracy R Luckhardt
Jeffrey C Horowitz
Subramaniam Pennathur
Fernando J Martinez
Victor J Thannickal
机构：
[1] University of Michigan Medical School,Division of Pulmonary and Critical Care Medicine
[2] University of Michigan Medical School,Division of Nephrology, Department of Internal Medicine
[3] Present address: Division of Pulmonary,undefined
[4] Allergy and Critical Care Medicine,undefined
[5] Department of Medicine,undefined
[6] University of Alabama at Birmingham,undefined
[7] Birmingham,undefined
[8] Alabama,undefined
[9] USA.,undefined
来源：
Nature Medicine | 2009年 / 15卷
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学科分类号：
摘要：
The mechanisms that lead to idiopathic pulmonary fibrosis, or lung scarring, is not clear. Victor Thannickal and his colleagues have now provided further insight by showing that induction of NOX4, an enzyme that creates reactive oxygen species, is required for the progression of the disease. Their findings suggest NOX4 as a potential target to treat this common ailment that currently has no proven treatment options.
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页码：1077 / 1081
页数：4
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