Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration

被引：0

作者：

Estelle Willems

Matthias Dedobbeleer

Marina Digregorio

Arnaud Lombard

Nicolas Goffart

Paul Noel Lumapat

Jeremy Lambert

Priscilla Van den Ackerveken

Martyna Szpakowska

Andy Chevigné

Felix Scholtes

Bernard Rogister

机构：

[1] University of Liège,Laboratory of Nervous System Diseases and Therapy, GIGA

[2] CHU of Liège,Neuroscience

[3] Luxembourg Institute of Health,Department of Neurosurgery

[4] CHU of Liège,Department of Infection and Immunity, Immuno

来源：

Oncogene | 2019年 / 38卷

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摘要：

Primary glioblastoma is the most frequent human brain tumor in adults and is generally fatal due to tumor recurrence. We previously demonstrated that glioblastoma-initiating cells invade the subventricular zones and promote their radio-resistance in response to the local release of the CXCL12 chemokine. In this work, we show that the mitotic Aurora A kinase (AurA) is activated through the CXCL12–CXCR4 pathway in an ERK1/2-dependent manner. Moreover, the CXCL12–ERK1/2 signaling induces the expression of Ajuba, the main cofactor of AurA, which allows the auto-phosphorylation of AurA.

引用

页码：73 / 87

页数：14

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