5′-Norcarbocyclic nucleoside analogs

被引：0
作者：
E. S. Matyugina
A. L. Khandazhinskaya
机构：
[1] V. A. Engelhardt Institute of Molecular Biology,
[2] of Russian Academy of Sciences,undefined
来源：
Russian Chemical Bulletin | 2014年 / 63卷
关键词：
5′-noraristeromycin; SAH hydrolase; antiviral activity; HIV; hepatitis B virus; target enzymes; tuberculosis;
D O I：
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中图分类号：
学科分类号：
摘要：
The present review briefly outlines main methods for the synthesis of 5′-norcarbocyclic nucleoside analogs and the biological activity spectrum of these compounds. Antiviral, antitumor, antibacterial, and anti-inflammatory properties of 5′-norcarbocyclic nucleoside analogs are described. Cellular enzymes, such as S-adenosylhomocysteine hydrolase, telomerase, adenosine kinase, and inosine monophosphate dehydrogenase, as well as HIV reverse transcriptase, are considered as target enzymes.
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页码：1069 / 1080
页数：11
相关论文
共 364 条
[1]  
Agrofoglio L(1994)undefined Tetrahedron 50 10611-undefined
[2]  
Suhas E(1968)undefined J. Antibiot. 21 255-undefined
[3]  
Farese A(1966)undefined J. Am. Chem. Soc. 88 3885-undefined
[4]  
Condom R(1987)undefined Antimicrob. Agents Chemother. 31 1849-undefined
[5]  
Challand S R(1990)undefined Tetrahedron Lett. 31 5861-undefined
[6]  
Earl R A(1988)undefined J. Am. Chem. Soc. 110 621-undefined
[7]  
Guedj R(1996)undefined Adv. Antiviral Drug Des. 2 41-undefined
[8]  
Kusaka T(2012)undefined Russ. Chem. Rev. 81 729-undefined
[9]  
Yamamoto H(1991)undefined Tetrahedron 47 7569-undefined
[10]  
Shibata M(2004)undefined Nucleosides, Nucleotides Nucleic Acids 23 67-undefined
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