The DNA-binding domain mediates both nuclear and cytosolic functions of p53

被引：0
作者：
Ariele Viacava Follis
Fabien Llambi
Li Ou
Katherine Baran
Douglas R Green
Richard W Kriwacki
机构：
[1] St. Jude Children's Research Hospital,Department of Structural Biology
[2] St. Jude Children's Research Hospital,Department of Immunology
[3] Immunology and Biochemistry,Department of Microbiology
[4] University of Tennessee Health Sciences Center,undefined
来源：
Nature Structural & Molecular Biology | 2014年 / 21卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Tumor suppressor p53 can activate BAX or BAK; this activity is opposed by antiapoptotic protein BCL-xL, which sequesters p53. Now Kriwacki, Green and colleagues characterize the human p53–BCL-xL complex by NMR spectroscopy, thus allowing mutagenesis analyses to dissect p53's nuclear and cytosolic functions and BCL-xL's antiapoptotic mechanisms.
引用
收藏
页码：535 / 543
页数：8
相关论文
共 165 条
  • [11] Kuwana T(1994)p53 domains: structure, oligomerization, and transformation Mol. Cell. Biol. 14 5182-5191
  • [12] Newmeyer DD(2004)Defining the p53 DNA-binding domain/Bcl-x(L)-binding interface using NMR FEBS Lett. 559 171-174
  • [13] Green DR(2007)Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL J. Biol. Chem. 282 29193-29200
  • [14] Sattler M(2010)BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain J. Biol. Chem. 285 3439-3450
  • [15] Petros AM(2013)Anti-apoptosis proteins Mcl-1 and Bcl-xL have different p53-binding profiles Biochemistry 52 6324-6334
  • [16] Feng W(2006)Structure of the Tfb1/p53 complex: insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53 Mol. Cell 22 731-740
  • [17] Huang S(2010)Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of CREB binding protein Biochemistry 49 9964-9971
  • [18] Wu H(2006)The N-terminal domain of tumor suppressor p53 is involved in the molecular interaction with the anti-apoptotic protein Bcl-Xl Biochem. Biophys. Res. Commun. 341 938-944
  • [19] Zhang M(2009)The MDM2-binding region in the transactivation domain of p53 also acts as a Bcl-X(L)-binding motif Biochemistry 48 12159-12168
  • [20] Liu X(2013)Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways J. Biol. Chem. 288 7387-7398
12345678910