Synthesis and pharmacological activity of 2-methoxyphenyl- and 2-oxyphenyl-substituted 1-dialkylaminoalkylimidazo [1,2-a]-benzimidazoles

被引：0
作者：
Anisimova V.A. [1 ]
Tolpygin I.E. [2 ]
Spasov A.A. [3 ]
Kosolapov V.A. [4 ]
Chernikov M.V. [3 ]
Stepanov A.V. [4 ]
Larionov V.P. [4 ]
机构：
[1] Institute of Physical and Organic Chemistry, Rostov State University, Rostov-on-Don
[2] Volga Region Scientific Center, Russian Academy of Medical Sciences, Volgograd
[3] Volgograd State Medical University, Volgograd
[4] Southern Scientific Center, Russian Academy of Sciences, Rostov-on-Don
来源：
Pharmaceutical Chemistry Journal | 2005年 / 39卷 / 11期
关键词：
Organic Chemistry; Serotonin; Purine; Good Prospect; Active Substance;
D O I：
10.1007/s11094-006-0024-8
中图分类号：
学科分类号：
摘要：
A series of 2-methoxy- and 2-oxyphenyl-1-dialkylaminoalkylimidazo[1,2-a] benzimidazoles have been synthesized and characterized with respect to pharmacological properties. Some of the synthesized compounds exhibit antioxidant, membranotropic, antiaggregant, hemorheological, anticalmodulin, and hypotensive properties, and behave as antagonists of serotonin (5-HT 2,3) and purine (P2Y1) receptors. The obtained data show good prospects for the synthesis and screening of biologically active substances in this class of compounds. © 2005 Springer Science+Business Media, Inc.
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收藏
页码：579 / 586
页数：7
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