Transcriptional control of natural killer cell differentiation and function

被引：0
|
作者：
Alfonso Martín-Fontecha
Graham M. Lord
Hugh J. M. Brady
机构：
[1] King’s College London,Medical Research Council (MRC) Centre for Transplantation, Guy’s Hospital
[2] Imperial College London,Section of Immunity and Infection, Cell and Molecular Biology Division, Department of Life Sciences, Immunology and Infection
来源：
Cellular and Molecular Life Sciences | 2011年 / 68卷
关键词：
Transcription factor; NK cell differentiation; Migration; Effector function;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Gene expression can be modulated depending on physiological and developmental requirements. A multitude of regulatory genes, which are organized in interdependent networks, guide development and eventually generate specific phenotypes. Transcription factors (TF) are a key element in the regulatory cascade controlling cell fate and effector functions. In this review, we discuss recent data on the diversity of TF that determine natural killer (NK) cell fate and NK cell function.
引用
收藏
页码：3495 / 3503
页数：8
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