Lipase-catalyzed esterification of unusual substrates: Synthesis of glucuronic acid and ascorbic acid (vitamin C) esters

被引：0
|
作者：
Ralf T. Otto
Uwe T. Bornscheuer
Holger Scheib
Jürgen Pleiss
Christoph Syldatk
Rolf D. Schmid
机构：
[1] University of Stuttgart,Institute of Biochemical Engineering
[2] University of Stuttgart,Institute of Technical Biochemistry
来源：
Biotechnology Letters | 1998年 / 20卷
关键词：
Candida antarctica; lipase; glucuronic acid; vitamin C;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The synthesis of n-butanol and cinnamic alcohol esters of glucuronic acid and the esterification of ascorbic acid (vitamin C) with phenylbutyric acid was performed with lipase from Candida antarctica B (CAL-B, SP435) in a mainly solid-phase system. Products were obtained in 15 to 22 % yield. Computer modelling based on the structure of CAL-B was used to elucidate the access of glucuronic acid to the catalytic site of the lipase. A fixation of glucuronic acid via H-bonds to Q157, D134 and H224 during the transition state was observed. © Rapid Science Ltd. 1998
引用
收藏
页码：1091 / 1094
页数：3
相关论文
共 50 条
  • [1] Lipase-catalyzed esterification of unusual substrates: Synthesis of glucuronic acid and ascorbic acid (vitamin C) esters
    Otto, RT
    Bornscheuer, UT
    Scheib, H
    Pleiss, J
    Syldatk, C
    Schmid, RD
    BIOTECHNOLOGY LETTERS, 1998, 20 (11) : 1091 - 1094
  • [2] Lipase-catalyzed synthesis of vitamin C fatty acid esters
    Yan, YC
    Bornscheuer, UT
    Schmid, RD
    BIOTECHNOLOGY LETTERS, 1999, 21 (12) : 1051 - 1054
  • [3] Lipase-catalyzed synthesis of vitamin C fatty acid esters
    Youchun Yan
    Uwe T. Bornscheuer
    Rolf D. Schmid
    Biotechnology Letters, 1999, 21 : 1051 - 1054
  • [4] Kinetic model of lipase-catalyzed conversion of ascorbic acid and oleic acid to liposoluble vitamin C ester
    Bezbradica, Dejan
    Stojanovic, Marija
    Velickovic, Dusan
    Dimitrijevic, Aleksandra
    Carevic, Milica
    Mihailovic, Mladen
    Milosavic, Nenad
    BIOCHEMICAL ENGINEERING JOURNAL, 2013, 71 : 89 - 96
  • [5] Lipase-catalyzed synthesis of fatty acid fructose esters
    Sabeder, Sasa
    Habulin, Maja
    Knez, Zeljko
    JOURNAL OF FOOD ENGINEERING, 2006, 77 (04) : 880 - 886
  • [6] Lipase-catalyzed esterification of glycerol and oleic acid
    Yesiloglu, Y
    Kilic, I
    JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 2004, 81 (03) : 281 - 284
  • [7] Lipase-catalyzed synthesis of kojic acid esters in organic solvents
    Liu, KJ
    Shaw, JF
    JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1998, 75 (11) : 1507 - 1511
  • [8] Lipase-catalyzed synthesis of β-methylglucoside esters containing an α-hydroxy acid
    Park, DW
    Kim, JS
    Haam, S
    Kim, HS
    Kim, WS
    BIOTECHNOLOGY LETTERS, 2001, 23 (23) : 1947 - 1952
  • [9] Lipase-Catalyzed Esterification of Geraniol and Citronellol for the Synthesis of Terpenic Esters
    Layane da Silva Corrêa
    Rosana Oliveira Henriques
    João Vitor Rios
    Lindomar Alberto Lerin
    Débora de Oliveira
    Agenor Furigo
    Applied Biochemistry and Biotechnology, 2020, 190 : 574 - 583
  • [10] Lipase-Catalyzed Esterification of Geraniol and Citronellol for the Synthesis of Terpenic Esters
    Correa, Layane da Silva
    Henriques, Rosana Oliveira
    Rios, Joao Vitor
    Lerin, Lindomar Alberto
    de Oliveira, Debora
    Furigo, Agenor, Jr.
    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2020, 190 (02) : 574 - 583
12345