Repriming of DNA synthesis at stalled replication forks by human PrimPol

被引：0

作者：

Silvana Mourón

Sara Rodriguez-Acebes

María I Martínez-Jiménez

Sara García-Gómez

Sandra Chocrón

Luis Blanco

Juan Méndez

机构：

[1] Molecular Oncology Program,Department of Genome Dynamics and Function

[2] Spanish National Cancer Research Centre,undefined

[3] Centro de Biología Molecular “Severo Ochoa”,undefined

来源：

Nature Structural & Molecular Biology | 2013年 / 20卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

DNA damage that causes replication forks to stall can be bypassed via translesion synthesis (TLS). New work has identified a bifunctional human primase and TLS polymerase, PrimPol, that reinitiates DNA synthesis beyond the damage site by virtue of its unique primase activity, revealing a novel pathway of DNA-damage tolerance.

引用

页码：1383 / 1389

页数：6

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