Repriming of DNA synthesis at stalled replication forks by human PrimPol

被引：0
|
作者：
Silvana Mourón
Sara Rodriguez-Acebes
María I Martínez-Jiménez
Sara García-Gómez
Sandra Chocrón
Luis Blanco
Juan Méndez
机构：
[1] Molecular Oncology Program,Department of Genome Dynamics and Function
[2] Spanish National Cancer Research Centre,undefined
[3] Centro de Biología Molecular “Severo Ochoa”,undefined
来源：
Nature Structural & Molecular Biology | 2013年 / 20卷
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摘要：
DNA damage that causes replication forks to stall can be bypassed via translesion synthesis (TLS). New work has identified a bifunctional human primase and TLS polymerase, PrimPol, that reinitiates DNA synthesis beyond the damage site by virtue of its unique primase activity, revealing a novel pathway of DNA-damage tolerance.
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页码：1383 / 1389
页数：6
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