Copy Number Variations and Schizophrenia

被引：0
作者：
Kamila Szecówka
Błażej Misiak
Izabela Łaczmańska
Dorota Frydecka
Ahmed A. Moustafa
机构：
[1] Wroclaw Medical University,Department of Genetics
[2] Wroclaw Medical University,Department of Psychiatry
[3] University of Johannesburg,Department of Human Anatomy and Physiology, The Faculty of Health Sciences
[4] Bond University,School of Psychology, Faculty of Society and Design, Centre of Data Analytics
来源：
Molecular Neurobiology | 2023年 / 60卷
关键词：
Schizophrenia; Genetics; Copy number variations (CNVs); Neural studies;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Schizophrenia is a neurodevelopmental disorder with genetic and environmental factors involved in its aetiology. Genetic liability contributing to the development of schizophrenia is a subject of extensive research activity, as reliable data regarding its aetiology would enable the improvement of its therapy and the development of new methods of treatment. A multitude of studies in this field focus on genetic variants, such as copy number variations (CNVs) or single-nucleotide variants (SNVs). Certain genetic disorders caused by CNVs including 22q11.2 microdeletion syndrome, Burnside-Butler syndrome (15q11.2 BP1-BP2 microdeletion) or 1q21.1 microduplication/microdeletion syndrome are associated with a higher risk of developing schizophrenia. In this article, we provide a unifying framework linking these CNVs and their associated genetic disorders with schizophrenia and its various neural and behavioural abnormalities.
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页码：1854 / 1864
页数：10
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