Copy Number Variations and Schizophrenia

被引：0
作者：
Kamila Szecówka
Błażej Misiak
Izabela Łaczmańska
Dorota Frydecka
Ahmed A. Moustafa
机构：
[1] Wroclaw Medical University,Department of Genetics
[2] Wroclaw Medical University,Department of Psychiatry
[3] University of Johannesburg,Department of Human Anatomy and Physiology, The Faculty of Health Sciences
[4] Bond University,School of Psychology, Faculty of Society and Design, Centre of Data Analytics
来源：
Molecular Neurobiology | 2023年 / 60卷
关键词：
Schizophrenia; Genetics; Copy number variations (CNVs); Neural studies;
D O I：
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中图分类号：
学科分类号：
摘要：
Schizophrenia is a neurodevelopmental disorder with genetic and environmental factors involved in its aetiology. Genetic liability contributing to the development of schizophrenia is a subject of extensive research activity, as reliable data regarding its aetiology would enable the improvement of its therapy and the development of new methods of treatment. A multitude of studies in this field focus on genetic variants, such as copy number variations (CNVs) or single-nucleotide variants (SNVs). Certain genetic disorders caused by CNVs including 22q11.2 microdeletion syndrome, Burnside-Butler syndrome (15q11.2 BP1-BP2 microdeletion) or 1q21.1 microduplication/microdeletion syndrome are associated with a higher risk of developing schizophrenia. In this article, we provide a unifying framework linking these CNVs and their associated genetic disorders with schizophrenia and its various neural and behavioural abnormalities.
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页码：1854 / 1864
页数：10
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  • [1] McGrath J(2008)Schizophrenia: a concise overview of incidence, prevalence, and mortality Epidemiol Rev 30 67-76
  • [2] Saha S(2018)Holistic management of schizophrenia symptoms using pharmacological and non-pharmacological treatment Front Public Heal 6 166-448
  • [3] Chant D(2016)Cognitive function in schizophrenia: conflicting findings and future directions Rev Neurosci 27 435-400
  • [4] Welham J(2014)Impairments of working memory in schizophrenia and bipolar disorder: the effect of history of psychotic symptoms and different aspects of cognitive task demands Front Behav Neurosci 8 416-147
  • [5] Ganguly P(2006)Deficit schizophrenia: association with serum antibodies to cytomegalovirus Schizophr Bull 32 396-565
  • [6] Soliman A(2008)Deficit schizophrenia: an update World Psychiatry 7 143-990
  • [7] Moustafa AA(2000)Neurological signs and the heterogeneity of schizophrenia Am J Psychiatry 157 560-327
  • [8] Moustafa AA(2002)Historical, psychopathological, neurological, and neuropsychological aspects of deficit schizophrenia: a multicenter study Am J Psychiatry 159 983-114
  • [9] Garami JK(2018)The genetics of neuropsychiatric disorders Brain Neurosci Adv 2 239821281879927-773
  • [10] Mahlberg J(2010)Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia Arch Gen Psychiatry 67 318-862
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