Pharmacokinetics of prolonged infusion of high-dose dexmedetomidine in critically ill patients

被引:0
作者
Timo Iirola
Riku Aantaa
Ruut Laitio
Erkki Kentala
Maria Lahtinen
Andrew Wighton
Chris Garratt
Tuula Ahtola-Sätilä
Klaus T Olkkola
机构
[1] University of Turku and Turku University Hospital,Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine
[2] University of Turku,Clinical Research Services Turku (CRST)
[3] CRST,undefined
[4] Orion Pharma R&D,undefined
[5] Orion Pharma,undefined
来源
Critical Care | / 15卷
关键词
Infusion Rate; Dexmedetomidine; Mean Arterial Blood Pressure; Simplify Acute Physiology Score; Liver Blood Flow;
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[1]  
Devlin JW(2010)Adverse drug events associated with the use of analgesics, sedatives, and antipsychotics in the intensive care unit Crit Care Med 38 S231-S243
[2]  
Mallow-Corbett S(2000)Pharmacokinetics and interaction pharmacodynamics of dexmedetomidine in humans Baillières Clin Anaesthesiol 14 261-269
[3]  
Riker RR(2000)Influence of cardiac output on dexmedetomidine pharmacokinetics J Pharm Sci 89 519-527
[4]  
Karol MD(1993)Alpha 2 adrenoceptor agonists and anaesthesia Br J Anaesth 71 108-118
[5]  
Maze M(2002)Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive care Br J Anaesth 88 669-675
[6]  
Dutta S(2002)The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients Am J Respir Crit Care Med 166 1338-1344
[7]  
Lal R(2004)Simultaneous quantitation of dexmedetomidine and glucuronide metabolites (G-Dex-1 and G-Dex-2) in human plasma utilizing liquid chromatography with tandem mass spectrometric detection Rapid Commun Mass Spectrom 18 1753-1760
[8]  
Karol MD(1993)A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study JAMA 270 2957-2963
[9]  
Cohen T(2003)National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification Ann Intern Med 139 137-147
[10]  
Ebert T(2010)Rate and extent of drug accumulation after multiple dosing revisited Clin Pharmacokinet 49 421-438