Risk factors for rising incidence of esophageal and gastric cardia adenocarcinoma

被引：68
作者：
Carr J.S. [1 ]
Zafar S.F. [2 ]
Saba N. [2 ]
Khuri F.R. [2 ]
El-Rayes B.F. [2 ]
机构：
[1] Department of Surgery, University of North Carolina, Chapel Hill, NC
[2] Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 300322
来源：
Journal of Gastrointestinal Cancer | 2013年 / 44卷 / 2期
关键词：
Esophageal adenocarcinoma; Gastric cardia adenocarcinoma; Risk factors;
D O I：
10.1007/s12029-013-9480-z
中图分类号：
学科分类号：
摘要：
Introduction In the last 30 years, the incidence of esophageal and gastric cardia adenocarcinoma has steadily increased. The increase in incidence is approximately seven-fold, which is a more substantial increase than that of several malignancies, including melanoma, breast cancer, and prostate cancer. Discussion The rising incidence has led to a steady increase in mortality from 2 to 15 deaths per 100,000 in the last three decades. The etiologic factors involved in the development of these malignancies include gastroesophageal reflux disease, Barrett's esophagus, acid-suppressivemedication use, obesity, and tobacco use. This article discusses the contribution of these etiologic risk factors to this increase in incidence. © Springer Science+Business Media New York 2013.
引用
收藏
页码：143 / 151
页数：8
相关论文
共 78 条
[61]  
Gammon M.D., Schoenberg J.B., Ahsan H., Et al., Tobacco, alcohol, and socioeconomic status and adenocarcinomas of the esophagus and gastric cardia, J Natl Cancer Inst, 89, pp. 1277-1284, (1997)
[62]  
Brown L.M., Silverman D.T., Pottern L.M., Et al., Adenocarcinoma of the esophagus and esophagogastric junction in white men in the United States: Alcohol, tobacco, and socioeconomic factors, Cancer Causes Control, 5, pp. 333-340, (1994)
[63]  
Lagergren J., Bergstrom R., Lindgren A., Nyren O., The role of tobacco, snuff and alcohol use in the aetiology of cancer of the oesophagus and gastric cardia, Int J Cancer, 85, pp. 340-346, (2000)
[64]  
Zhao D.L., Chen W.Q., Yu T.T., Et al., A population-based matched case-control study on the risk factors of gastric cardia cancer, Zhonghua Zhong Liu Za Zhi, 33, pp. 775-778, (2011)
[65]  
Cook M.B., Kamangar F., Whiteman D.C., Et al., Cigarette smoking and adenocarcinomas of the esophagus and esophagogastric junction: A pooled analysis from the international BEACON consortium, J Natl Cancer Inst, 102, pp. 1344-1353, (2010)
[66]  
Pandeya N., Webb P.M., Sadeghi S., Et al., Gastro-oesophageal reflux symptoms and the risks of oesophageal cancer: Are the effects modified by smoking, NSAIDs or acid suppressants?, Gut, 59, pp. 31-38, (2010)
[67]  
El-Serag H.B., Aguirre T.V., Davis S., Et al., Proton pump inhibitors are associated with reduced incidence of dysplasia in Barrett's esophagus, Am J Gastroenterol, 99, pp. 1877-1883, (2004)
[68]  
Hillman L.C., Chiragakis L., Shadbolt B., Et al., Proton-pump inhibitor therapy and the development of dysplasia in patients with Barrett's oesophagus, Med J Aust, 180, pp. 387-391, (2004)
[69]  
De Jonge P.J., Siersema P.D., Van Breda S.G., Et al., Proton pump inhibitor therapy in gastro-oesophageal reflux disease decreases the oesophageal immune response but does not reduce the formation of DNA adducts, Aliment Pharmacol Ther, 28, pp. 127-136, (2008)
[70]  
Hillman L.C., Chiragakis L., Shadbolt B., Et al., Effect of proton pump inhibitors on markers of risk for high-grade dysplasia and oesophageal cancer in Barrett's oesophagus, Aliment Pharmacol Ther, 27, pp. 321-326, (2008)
12345678