Risk factors for rising incidence of esophageal and gastric cardia adenocarcinoma

被引：66
作者：
Carr J.S. [1 ]
Zafar S.F. [2 ]
Saba N. [2 ]
Khuri F.R. [2 ]
El-Rayes B.F. [2 ]
机构：
[1] Department of Surgery, University of North Carolina, Chapel Hill, NC
[2] Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 300322
来源：
Journal of Gastrointestinal Cancer | 2013年 / 44卷 / 2期
关键词：
Esophageal adenocarcinoma; Gastric cardia adenocarcinoma; Risk factors;
D O I：
10.1007/s12029-013-9480-z
中图分类号：
学科分类号：
摘要：
Introduction In the last 30 years, the incidence of esophageal and gastric cardia adenocarcinoma has steadily increased. The increase in incidence is approximately seven-fold, which is a more substantial increase than that of several malignancies, including melanoma, breast cancer, and prostate cancer. Discussion The rising incidence has led to a steady increase in mortality from 2 to 15 deaths per 100,000 in the last three decades. The etiologic factors involved in the development of these malignancies include gastroesophageal reflux disease, Barrett's esophagus, acid-suppressivemedication use, obesity, and tobacco use. This article discusses the contribution of these etiologic risk factors to this increase in incidence. © Springer Science+Business Media New York 2013.
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页码：143 / 151
页数：8
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