Risk factors for rising incidence of esophageal and gastric cardia adenocarcinoma

被引：68
作者：
Carr J.S. [1 ]
Zafar S.F. [2 ]
Saba N. [2 ]
Khuri F.R. [2 ]
El-Rayes B.F. [2 ]
机构：
[1] Department of Surgery, University of North Carolina, Chapel Hill, NC
[2] Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 300322
来源：
Journal of Gastrointestinal Cancer | 2013年 / 44卷 / 2期
关键词：
Esophageal adenocarcinoma; Gastric cardia adenocarcinoma; Risk factors;
D O I：
10.1007/s12029-013-9480-z
中图分类号：
学科分类号：
摘要：
Introduction In the last 30 years, the incidence of esophageal and gastric cardia adenocarcinoma has steadily increased. The increase in incidence is approximately seven-fold, which is a more substantial increase than that of several malignancies, including melanoma, breast cancer, and prostate cancer. Discussion The rising incidence has led to a steady increase in mortality from 2 to 15 deaths per 100,000 in the last three decades. The etiologic factors involved in the development of these malignancies include gastroesophageal reflux disease, Barrett's esophagus, acid-suppressivemedication use, obesity, and tobacco use. This article discusses the contribution of these etiologic risk factors to this increase in incidence. © Springer Science+Business Media New York 2013.
引用
收藏
页码：143 / 151
页数：8
相关论文
共 78 条
[41]  
Reid B.J., P53 and neoplastic progression in Barrett's esophagus, Am J Gastroenterol, 96, pp. 1321-1323, (2001)
[42]  
Wong D.J., Paulson T.G., Prevo L.J., Et al., P16(INK4a) lesions are common, early abnormalities that undergo clonal expansion in Barrett's metaplastic epithelium, Cancer Res, 61, pp. 8284-8289, (2001)
[43]  
Schulmann K., Sterian A., Berki A., Et al., Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk, Oncogene, 24, pp. 4138-4148, (2005)
[44]  
Galipeau P.C., Li X., Blount P.L., Et al., NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinoma, PLoS Med, 4, (2007)
[45]  
Vaughan T.L., Davis S., Kristal A., Thomas D.B., Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: Adenocarcinoma versus squamous cell carcinoma, Cancer Epidemiol Biomarkers Prev, 4, pp. 85-92, (1995)
[46]  
Merry A.H., Schouten L.J., Goldbohm R.A., Van Den Brandt P.A., Body mass index, height and risk of adenocarcinoma of the oesophagus and gastric cardia: A prospective cohort study, Gut, 56, pp. 1503-1511, (2007)
[47]  
Lagergren J., Bergstrom R., Nyren O., Association between body mass and adenocarcinoma of the esophagus and gastric cardia, Ann Intern Med, 130, pp. 883-890, (1999)
[48]  
Whiteman D.C., Sadeghi S., Pandeya N., Et al., Combined effects of obesity, acid reflux and smoking on the risk of adenocarcinomas of the oesophagus, Gut, 57, pp. 173-180, (2008)
[49]  
Corley D.A., Kubo A., Zhao W., Abdominal obesity and the risk of esophageal and gastric cardia carcinomas, Cancer Epidemiol Biomarkers Prev, 17, pp. 352-358, (2008)
[50]  
Hampel H., Abraham N.S., El-Serag H.B., Meta-analysis: Obesity and the risk for gastroesophageal reflux disease and its complications, Ann Intern Med, 143, pp. 199-211, (2005)
12345678