Sodium alendronate used in bone treatment

被引：12

作者：

Doca, Sorin Cristian ^{[1
]}

Albu, Paul ^{[2
,3
]}

Ceban, Iulia ^{[2
]}

Anghel, Andrei ^{[1
]}

Vlase, Gabriela ^{[2
]}

Vlase, Titus ^{[2
]}

机构：

[1] Univ Med & Farm Timisoara, Eftimie Murgu Sq 2, Timisoara 300041, Romania

[2] West Univ Timisoara, Res Ctr Thermal Anal Environm Problems, 16 Pestalozzi St, Timisoara 300115, Romania

[3] Vasile Goldis West Univ Arad, Fac Pharm, Dept Pharmaceut Sci, 86 L Rebreanu St, Arad 310414, Romania

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2016年 / 126卷 / 01期

关键词：

Sodium alendronate-excipient mixture; Thermally induced interactions; Heat flow signal interpretations; THERMAL-BEHAVIOR; DOSAGE FORMS; OSSEOINTEGRATION; COMPATIBILITY; DEGRADATION; EXCIPIENTS; NECROSIS; RATS;

D O I：

10.1007/s10973-016-5619-z

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The thermally induced interactions of sodium alendronate trihydrate in 1:1 mass ratio binary mixture with talc, silica, magnesium stearate, microcrystalline cellulose, starch, gelatin and mannitol were studied under non-isothermal conditions. The heat flow (HF) signal, obtained by converting the temperature differences (DTA) into power units, was used for detecting the thermally induced events. By all the seven excipients, no thermally induced interactions with alendronate were observed, but the thermal stability of the excipients is very different. The talc and silica, as expected, are very thermostable. By starch, gelatin, and microcrystalline cellulose, the HF signal corresponding to the thermo degradation is over 270 A degrees C, the deamination step of alendronate. The magnesium stearate and mannitol substances are not recommended for solid formulation due to its low thermal stability.

引用

页码：189 / 194

页数：6

共 17 条

[1]

Albu P, J THERM ANA IN PRESS

[2] Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment [J].

Allen, Matthew R. ;

Burr, David B. .

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2008, 66 (05) :987-994

[3]

*AM DENT ASS, 2008, DENT MAN PAT REC OR

[4]

Atyol UK, 2015, LASER MED SCI, V30, P1141

[5] Drug-excipient compatibility studies in binary and ternary mixtures by physico-chemical techniques [J].

Bruni, Giovanna ;

Berbenni, Vittorio ;

Milanese, Chiara ;

Girella, Alessandro ;

Marini, Amedeo .

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2010, 102 (01) :193-201

[6] Zoledronic acid enhances bone-implant osseointegration more than alendronate and strontium ranelate in ovariectomized rats [J].

Chen, B. ;

Li, Y. ;

Yang, X. ;

Xu, H. ;

Xie, D. .

OSTEOPOROSIS INTERNATIONAL, 2013, 24 (07) :2115-2121

[7] Comparison of the effects of alendronate sodium and calcitonin on bone-prosthesis osseointegration in osteoporotic rats [J].

Chen, B. -L. ;

Xie, D. -H. ;

Zheng, Z. -M. ;

Lu, W. ;

Ning, C. -Y. ;

Li, Y. -Q. ;

Li, F. -B. ;

Liao, W. -M. .

OSTEOPOROSIS INTERNATIONAL, 2011, 22 (01) :265-270

[8] Trimethylsilyldiazomethane derivatization coupled with solid-phase extraction for the determination of alendronate in human plasma by LC-MS/MS [J].

Chen, Meixia ;

Liu, Ke ;

Zhong, Dafang ;

Chen, Xiaoyan .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2012, 402 (02) :791-798

[9]

Fulias A, 2013, CHEM CENT J, V7, DOI [10.1186/1752-153X-7-140, 10.1186/1752-153X-7-70]

[10] Physico-chemical solid-state characterization of pharmaceutical pyrazolones: An unexpected thermal behaviour [J].

Fulias, Adriana ;

Ledeti, Ionut ;

Vlase, Gabriela ;

Vlase, Titus .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2013, 81-82 :44-49

← 1 2 →