Clinical validity of the Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB) in Mild Cognitive Impairment and Alzheimer's Disease

被引：1

作者：

Conca, Francesca ^{[1
]}

Esposito, Valentina ^{[2
]}

Catricala, Eleonora ^{[1
]}

Manenti, Rosa ^{[3
]}

L'Abbate, Federica ^{[4
]}

Quaranta, Davide ^{[4
,5
]}

Giuffre, Guido Maria ^{[4
]}

Rossetto, Federica ^{[6
]}

Solca, Federica ^{[7
]}

Orso, Beatrice ^{[8
]}

Inguscio, Emanuela ^{[9
]}

Crepaldi, Valeria ^{[9
]}

De Matteis, Maddalena ^{[10
]}

Rotondo, Emanuela ^{[11
]}

Manera, Marina ^{[12
]}

Caruso, Giulia ^{[13
]}

Catania, Valentina ^{[14
]}

Canu, Elisa ^{[15
]}

Rundo, Francesco ^{[14
]}

Ramusino, Matteo Cotta ^{[2
]}

Filippi, Massimo ^{[15
,16
,17
]}

Fundaro, Cira ^{[18
]}

Piras, Federica ^{[13
]}

Arighi, Andrea ^{[11
]}

Tiraboschi, Pietro ^{[9
]}

Maserati, Michelangelo Stanzani ^{[10
]}

Pardini, Matteo ^{[8
,19
]}

Poletti, Barbara ^{[7
,20
]}

Silani, Vincenzo ^{[7
,21
]}

Marra, Camillo ^{[4
,5
]}

Di Tella, Sonia ^{[5
,6
]}

Cotelli, Maria ^{[3
]}

Lodi, Raffaele ^{[10
]}

Tagliavini, Fabrizio ^{[9
]}

Cappa, Stefano Francesco ^{[1
,2
]}

机构：

[1] Inst Adv Studies, ICoN Cognit Neurosci Ctr, IUSS, Pavia, Italy

[2] IRCCS Mondino Fdn, Pavia, Italy

[3] IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Neuropsychol Unit, Brescia, Italy

[4] Fdn Policlin Univ A Gemelli IRCCS, Neurol Unit, Rome, Italy

[5] Univ Cattolica Sacro Cuore, Dept Psychol, Milan, Italy

[6] IRCCS Fdn Don Carlo Gnocchi, ONLUS, Milan, Italy

[7] IRCCS Ist Auxol Italiano, Dept Neurol & Lab Neurosci, Milan, Italy

[8] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy

[9] Fdn IRCCS Ist Neurol Carlo Besta, Milan, Italy

[10] IRCCS Ist Sci Neurolog Bologna, Bologna, Italy

[11] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Neurodegenerat Dis Unit, Milan, Italy

[12] Ist Clinici Scientif Maugeri IRCCS, Psychol Unit Pavia Montescano, Istituti Clinici Scientif Maugeri IRCCS, Pavia, Italy

[13] IRCCS Fdn St Lucia, Clin Neurosci & Neurorehabil Dept, Neuropsychiat Lab, Rome, Italy

[14] Oasi Res Inst IRCCS, Troina, Italy

[15] IRCCS San Raffaele Sci Inst, Div Neurosci, Neuroimaging Res Unit, Milan, Italy

[16] IRCCS San Raffaele Sci Inst, Neurophysiol Serv, Neurol Unit, Neurorehabil Unit, Milan, Italy

[17] Univ Vita Salute San Raffaele, Milan, Italy

[18] Ist Clinici Scientif Maugeri IRCCS, Neurophysiopatol Unit Pavia Montescano, Istituti Clinici Scientif Maugeri IRCCS, Pavia, Italy

[19] IRCCS Osped Policlin S Martino, Genoa, Italy

[20] Univ Milan, Dept Oncol & Hemato Oncol, Milan, Italy

[21] Univ Milan, Dino Ferrari Ctr, Dept Pathophysiol & Transplantat, Milan, Italy

来源：

ALZHEIMERS RESEARCH & THERAPY | 2024年 / 16卷 / 01期

关键词：

Neuropsychological tests; UDS; Alzheimer's Disease; Mild Cognitive Impairment; Cognition; MENTAL-STATE-EXAMINATION; NATIONAL INSTITUTE; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; MEMORY; DEMENTIA; DEFICITS; RECOMMENDATIONS; SENSITIVITY; DYSFUNCTION;

D O I：

10.1186/s13195-024-01465-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background The identification and staging of Alzheimer's Disease (AD) represent a challenge, especially in the prodromal stage of Mild Cognitive Impairment (MCI), when cognitive changes can be subtle. Worldwide efforts were dedicated to select and harmonize available neuropsychological instruments. In Italy, the Italian Network of Neuroscience and Neuro-Rehabilitation has promoted the adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB), collecting normative data from 433 healthy controls (HC). Here, we aimed to explore the ability of I-UDSNB to differentiate between a) MCI and HC, b) AD and HC, c) MCI and AD.Background The identification and staging of Alzheimer's Disease (AD) represent a challenge, especially in the prodromal stage of Mild Cognitive Impairment (MCI), when cognitive changes can be subtle. Worldwide efforts were dedicated to select and harmonize available neuropsychological instruments. In Italy, the Italian Network of Neuroscience and Neuro-Rehabilitation has promoted the adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB), collecting normative data from 433 healthy controls (HC). Here, we aimed to explore the ability of I-UDSNB to differentiate between a) MCI and HC, b) AD and HC, c) MCI and AD.Methods One hundred thirty-seven patients (65 MCI, 72 AD) diagnosed after clinical-neuropsychological assessment, and 137 HC were included. We compared the I-UDSNB scores between a) MCI and HC, b) AD and HC, c) MCI and AD, with t-tests. To identify the test(s) most capable of differentiating between groups, significant scores were entered in binary logistic and in stepwise regressions, and then in Receiver Operating Characteristic curve analyses.Results Two episodic memory tests (Craft Story and Five Words test) differentiated MCI from HC subjects; Five Words test, Semantic Fluency (vegetables), and TMT-part B differentiated AD from, respectively, HC and MCI.Conclusions Our findings indicate that the I-UDSNB is a suitable tool for the harmonized and concise assessment of patients with cognitive decline, showing high sensitivity and specificity for the diagnosis of MCI and AD.

引用

页数：9

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