Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients

被引:0
作者
Xiao-Man Chu
Li-Fang Zhang
Guang-Ji Wang
Shen-Ning Zhang
Jia-Hui Zhou
Hai-Ping Hao
机构
[1] Jinling Hospital,Department of Clinical Pharmacology
[2] China Pharmaceutical University,State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism & Pharmacokinetics
[3] Jinling Hospital,Department of Neurology
来源
European Journal of Clinical Pharmacology | 2012年 / 68卷
关键词
Valproic acid; UDP-glucuronosyltransferase; Polymorphisms; Pharmacokinetics; Drug combination;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1395 / 1401
页数:6
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[1]  
Rogawski MA(2004)The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions Nat Med 10 685-692
[2]  
Loscher W(2007)Valproic acid for the treatment of myeloid malignancies Cancer 110 943-954
[3]  
Kuendgen A(2003)Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs Lancet Neurol 2 473-481
[4]  
Gattermann N(2004)Mechanism of the drug interaction between valproic acid and carbapenem antibiotics in monkeys and rats Drug Metab Dispos 32 1383-1391
[5]  
Patsalos PN(2006)Clinically relevant drug interactions with antiepileptic drugs Br J Clin Pharmacol 61 246-255
[6]  
Perucca E(2008)Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects Clin Pharmacol Ther 83 595-600
[7]  
Nakajima Y(1998)A mechanistic approach to antiepileptic drug interactions Ann Pharmacother 32 554-563
[8]  
Mizobuchi M(1988)Clinical pharmacokinetics of valproic acid—1988 Clin Pharmacokinet 15 367-389
[9]  
Nakamura M(2000)Urinary excretion of valproate metabolites in children and adolescents Biopharm Drug Dispos 21 327-330
[10]  
Perucca E(1989)Urinary excretion of valproate and some metabolites in chronically treated patients Ther Drug Monit 11 127-133