Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia

[1] von Vietinghoff S(2008)Homeostatic regulation of blood neutrophil counts J Immunol 181 5183-5188

[2] Ley K(2010)The bone marrow: a site of neutrophil clearance J Leukoc Biol 88 241-251

[3] Rankin SM(1994)Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization Blood 84 1737-1746

[4] Lieschke GJ(1996)Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice Immunity 5 491-501

[5] Grail D(1998)IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines J Immunol 161 6383-6389

[6] Hodgson G(2009)IL-17 and Th17 cells Annu Rev Immunol 27 485-517

[7] Metcalf D(2013)IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis J Clin Invest 123 247-260

[8] Stanley E(2010)Innate IL-17-producing cells: the sentinels of the immune system Nat Rev Immunol 10 479-489

[9] Cheers C(2000)Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation Science 287 1049-1053

[10] Fowler KJ(2012)The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock Nat Immunol 13 1045-1054

[1] von Vietinghoff S(2008)Homeostatic regulation of blood neutrophil counts J Immunol 181 5183-5188

[2] Ley K(2010)The bone marrow: a site of neutrophil clearance J Leukoc Biol 88 241-251

[3] Rankin SM(1994)Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization Blood 84 1737-1746

[4] Lieschke GJ(1996)Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice Immunity 5 491-501

[5] Grail D(1998)IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines J Immunol 161 6383-6389

[6] Hodgson G(2009)IL-17 and Th17 cells Annu Rev Immunol 27 485-517

[7] Metcalf D(2013)IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis J Clin Invest 123 247-260

[8] Stanley E(2010)Innate IL-17-producing cells: the sentinels of the immune system Nat Rev Immunol 10 479-489

[9] Cheers C(2000)Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation Science 287 1049-1053

[10] Fowler KJ(2012)The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock Nat Immunol 13 1045-1054