Neuro-regenerative potential of dental stem cells: a concise review

被引:0
作者
Duaa Abuarqoub
Nazneen Aslam
Bayan Almajali
Leen Shajrawi
Hanan Jafar
Abdalla Awidi
机构
[1] University of Petra,Department of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences
[2] The University of Jordan,Cell Therapy Center
[3] The University of Jordan,School of Medicine
来源
Cell and Tissue Research | 2020年 / 382卷
关键词
Dental; Stem cells; Differentiation; Neuro-regeneration; Neuro-degenerative disorders;
D O I
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中图分类号
学科分类号
摘要
This review will summarize the research information regarding the regenerative potential of dental stem cells for the treatment of neurodegenerative disorders. As compared to existing treatment modalities, the stem cell therapy seems promising, and accumulating evidences about the differentiation of stem cells into various lineages are proving it. The incidence of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, stroke, and peripheral neuropathy is increasing due to the rise in life expectancies of people which have put a huge burden on economies. Finding a promising treatment could benefit not only the patients but also the communities. Dental stem cells hold a great potential to differentiate into neuronal cells. Many studies have reported the differentiation potential of the dental stem cells with the presence of neuronal lineage markers. In this review, we conferred how the use of dental stem cells can benefit the above-mentioned bedridden diseases.
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页码:267 / 279
页数:12
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  • [61] Chun SY(2015)Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer’s disease Behav Brain Res 293 5807-90
  • [62] Soker S(2003)SHED: stem cells from human exfoliated deciduous teeth Proc Natl Acad Sci U S A 100 155-3372
  • [63] Jang Y-J(2005)Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth Matrix biology : journal of the International Society for Matrix Biology 24 120-830
  • [64] Kwon TG(2001)Dental pulp cells produce neurotrophic factors, interact with trigeminal neurons in vitro, and rescue motoneurons after spinal cord injury Dev Biol 238 189-983
  • [65] Yoo ES(2011)Induced in vitro differentiation of neural-like cells from human exfoliated deciduous teeth-derived stem cells Int J Dev Biol 55 277-508
  • [66] Dai L-G(2010)Bone marrow mesenchymal stem cells J Cell Biochem 109 485-2699
  • [67] Huang G-S(2016)Transplantation of dental pulp stem cells suppressed inflammation in sciatic nerves by promoting macrophage polarization towards anti-inflammation phenotypes and ameliorated diabetic polyneuropathy Journal of diabetes investigation 7 352-1311
  • [68] S-h H(2014)Neurogenic differentiation of human dental pulp stem cells using different induction protocols Oral Dis 20 1029-1802
  • [69] d'Aquino R(2014)Functional recovery after repair of peroneal nerve gap using different collagen conduits Acta Neurochir 156 245-162
  • [70] Graziano A(2018)Mechanisms underlying dental-derived stem cell-mediated neurorestoration in neurodegenerative disorders Stem Cell Res Ther 9 80-730