Cord blood versus age 5 mononuclear cell proliferation on IgE and asthma

被引：9

作者：

Chang C. ^{[1
]}

Gauvey-Kern K. ^{[1
]}

Johnson A. ^{[1
]}

Kelvin E.A. ^{[2
]}

Chew G.L. ^{[2
]}

Perera F. ^{[2
]}

Miller R.L. ^{[1
,2
,3
]}

机构：

[1] Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY

[2] Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY

[3] Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY

来源：

Clinical and Molecular Allergy | / 8卷 / 1期

关键词：

Asthma; Cord Blood; Indoor Allergen; Cockroach Allergen; Allergen Level;

D O I：

10.1186/1476-7961-8-11

中图分类号：

学科分类号：

摘要：

Background: Fetal immune responses following exposure of mothers to allergens during pregnancy may influence the subsequent risk of childhood asthma. However, the association of allergen-induced cord blood mononuclear cell (CBMC) proliferation and cytokine production with later allergic immune responses and asthma has been controversial. Our objective was to compare indoor allergen-induced CBMC with age 5 peripheral blood mononuclear cell (PBMC) proliferation and determine which may be associated with age 5 allergic immune responses and asthma in an inner city cohort.Methods: As part of an ongoing cohort study of the Columbia Center for Children's Environmental Health (CCCEH), CBMCs and age 5 PBMCs were cultured with cockroach, mouse, and dust mite protein extracts. CBMC proliferation and cytokine (IL-5 and IFN-γ) responses, and age 5 PBMC proliferation responses, were compared to anti-cockroach, anti-mouse, and anti-dust mite IgE levels, wheeze, cough, eczema and asthma.Results: Correlations between CBMC and age 5 PBMC proliferation in response to cockroach, mouse, and dust mite antigens were nonsignificant. Cockroach-, mouse-, and dust mite-induced CBMC proliferation and cytokine responses were not associated with allergen-specific IgE at ages 2, 3, and 5, or with asthma and eczema at age 5. However, after adjusting for potential confounders, age 5 cockroach-induced PBMC proliferation was associated with anti-cockroach IgE, total IgE, and asthma (p < 0.05).Conclusion: In contrast to allergen-induced CBMC proliferation, age 5 cockroach-induced PBMC proliferation was associated with age 5 specific and total IgE, and asthma, in an inner-city cohort where cockroach allergens are prevalent and exposure can be high. © 2010 Chang et al; licensee BioMed Central Ltd.

引用

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