Effects of retinoids on the generation of neutrophil-derived reactive oxygen species studied by EPR spin trapping techniques

被引：0

作者：

M. Bohne

H. Struy

A. Gerber

H. Gollnick

机构：

[1] Department of Dermatology and Venereology,

[2] Otto-von-Guericke University,undefined

[3] Leipziger Str. 44,undefined

[4] D-39120 Magdeburg,undefined

[5] Germany,undefined

[6] Fax +49 391 671 5235,undefined

[7] e-mail: Marisela.bohne@medizin.uni-magdeburg.de,undefined

[8] Department of Immunology,undefined

[9] Otto-von-Guericke University,undefined

[10] Leipziger Str. 44,undefined

[11] D-39120 Magdeburg,undefined

[12] Germany,undefined

来源：

Inflammation Research | 1997年 / 46卷

关键词：

Key words: Retinoids — Acitretin — Isotretinoin — Reactive oxygen species;

D O I：

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学科分类号：

摘要：

Objective: To study the potential efficacy of retinoids on granulocytes with regard to their role in inflammatory dermatoses.¶Methods: We investigated the in vitro effect of acitretin and isotretinoin on the generation of reactive oxygen species (ROS) by stimulated human neutrophils using EPR spin trapping techniques.¶Results: The effects of the two retinoids on ROS generation by neutrophils were different. Acitretin increased the generation of hydroxyl radicals, whereas isotretinoin showed an antioxidant activity against the superoxide anion.¶Conclusions: Our study demonstrates retinoid type-dependent effects on ROS production by stimulated neutrophils.

引用

页码：423 / 424

页数：1