Allylic protection of thiols and cysteine. III. Use of Fmoc-Cys(Fsam)-OH for solid-phase peptide synthesis

被引：5
作者：
Gomez-Martinez P. [1 ,2 ]
Guibé F. [1 ]
Albericio F. [2 ]
机构：
[1] Institut de Chimie Moléculaire d'Orsay, Laboratoire de Catalyse Moléculaire, Université Paris-Sud
[2] Department of Organic Chemistry, University of Barcelona
来源：
Letters in Peptide Science | 2000年 / 7卷 / 4期
关键词：
Cystine; Disulfide formation; Pd chemistry; Protecting group;
D O I：
10.1023/A:1011299012894
中图分类号：
学科分类号：
摘要：
The solid-phase synthesis of peptides containing Cys has been carried out using the new thiol protecting group Fsam, which is completely stable to basic and acidic conditions used in both main strategies and can be selectively removed by palladium-catalyzed allylic cleavage in the presence of nucleophiles. This protecting group adds a new dimension of orthogonality for regioselective cysteine pairing strategies.
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页码：187 / 194
页数：7
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