Implementing prognostic and predictive biomarkers in CRC clinical trials

被引：0
作者：
Sandra Van Schaeybroeck
Wendy L. Allen
Richard C. Turkington
Patrick G. Johnston
机构：
[1] Drug Resistance Group,
[2] Centre for Cancer Research and Cell Biology,undefined
[3] Queen's University Belfast,undefined
来源：
Nature Reviews Clinical Oncology | 2011年 / 8卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
KRASrepresents the first biomarker to be integrated in clinical practice for the treatment of colorectal cancer. However, clinical study design, reproducibility, interpretation and reporting of the clinical data remain important challenges. This Review highlights the clinical application of published prognostic and predictive protein and genomic markers and the possibilities offered by novel adaptive clinical trial designs.
引用
收藏
页码：222 / 232
页数：10
相关论文
共 176 条
[1]  
Benson AB(2004)American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer J. Clin. Oncol. 22 3408-3419
[2]  
Boland CR(1998)A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer Cancer Res. 58 5248-5257
[3]  
Tejpar S(2009)Microsatellite instability (MSI) in stage II and III colon cancer treated with 5FU-LV or 5FU-LV and irinotecan (PETACC 3-EORTC 40993-SAKK 60/00 trial) [abstract] J. Clin. Oncol. 27 a4001-273
[4]  
Koopman M(2009)Deficient mismatch repair system in patients with sporadic advanced colorectal cancer Br. J. Cancer 100 266-1206
[5]  
Watanabe T(2001)Molecular predictors of survival after adjuvant chemotherapy for colon cancer N. Engl. J. Med. 344 1196-257
[6]  
Ribic CM(2003)Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer N. Engl. J. Med. 349 247-3415
[7]  
French AJ(2008)Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer Clin. Cancer Res. 14 3408-618
[8]  
Popat S(2005)Systematic review of microsatellite instability and colorectal cancer prognosis J. Clin. Oncol. 23 609-1750
[9]  
Hubner R(2010)Value of mismatch repair, J. Clin. Oncol. 28 a3517-3226
[10]  
Houlston RS(2010), and J. Clin. Oncol. 28 a3519-1821
12345678910