Leser-Trélat sign presenting in a patient with ovarian cancer: A case report

被引：4

作者：

Bölke E. ^{[1
]}

Gerber P.A. ^{[2
]}

Peiper M. ^{[3
]}

Knoefel W.T. ^{[3
]}

Cohnen M. ^{[4
]}

Matuschek C. ^{[1
]}

Budach W. ^{[1
]}

Engers R. ^{[5
]}

Gripp S. ^{[1
]}

机构：

[1] Department of Radiation Therapy and Radiation Oncology, University of Düsseldorf, 40225 Düsseldorf

[2] Department of Dermatology, University of Düsseldorf, 40225 Düsseldorf

[3] Department of Surgery, University of Düsseldorf, 40225 Düsseldorf

[4] Institute of Diagnostic Radiology, University of Düsseldorf, 40225 Düsseldorf

[5] Department of Pathology, University of Düsseldorf, 40225 Düsseldorf

来源：

Journal of Medical Case Reports | / 3卷 / 1期

关键词：

Peritoneal Carcinomatosis; Papillary Adenocarcinoma; Acanthosis Nigricans; Transform Growth Factor Alpha; Occult Cancer;

D O I：

10.4076/1752-1947-3-8583

中图分类号：

学科分类号：

摘要：

Introduction. Seborrheic keratoses are very common findings in elderly patients. However, a sudden onset and dramatic increase in the number and size of these benign lesions deserves special attention, since this may represent the Leser Trélat sign, a rare paraneoplastic cutaneous syndrome. Case presentation. A 92-year-old female presented to our clinic with multiple eruptive seborrheic keratoses, which had dramatically increased in size and number over the past two years. A diagnostic work-up revealed an ovarian carcinoma. Hence, cutaneous findings in our patient were consistent with the diagnosis of the Leser-Trélat sign. Conclusion. The Leser-Trélat sign may coincide with the diagnosis of occult cancer or follow or precede it by months or years. Practitioners should take cases of eruptive seborrheic keratoses seriously and perform thorough patient examinations. © 2009 licensee BioMed Central Ltd.

引用

共 10 条

[1] Schwartz R.A., Sign of Leser-Trelat, J Am Acad Dermatol, 35, pp. 88-95, (1996)
[2] Holdiness M.R., On the classification of the sign of Leser-Trelat, J Am Acad Dermatol, 19, pp. 754-757, (1988)
[3] Ashour A.A., Verschraegen C.F., Kudelka A.P., Kavanagh J.J., Paraneoplastic syndromes of gynecologic neoplasms, J Clin Oncol, 15, pp. 1272-1282, (1997)
[4] Kurzrock R., Cohen P.R., Cutaneous paraneoplastic syndromes in solid tumors, Am J Med, 99, pp. 662-671, (1995)
[5] Kilickap S., Yalcin B., Images in clinical medicine. the sign of Leser-Trelat, N Engl J Med, 356, (2007)
[6] Heaphy Jr. M.R., Millns J.L., Schroeter A.L., The sign of Leser-Trelat in a case of adenocarcinoma of the lung, J Am Acad Dermatol, 43, pp. 386-390, (2000)
[7] Kebria M.M., Belinson J., Kim R., Mekhail T.M., Malignant acanthosis nigricans, tripe palms and the sign of Leser-Trelat, a hint to the diagnosis of early stage ovarian cancer: A case report and review of the literature, Gynecol Oncol, 101, pp. 353-355, (2006)
[8] Horiuchi Y., Katsuoka K., Takezaki S., Nishiyama S., Study of epidermal growth activity in cultured human keratinocytes from peripheral-blood lymphocytes of a patient with Sezary syndrome associated with the Leser-Trelat sign, Arch Dermatol Res, 278, pp. 74-76, (1985)
[9] Ellis D.L., Kafka S.P., Chow J.C., Nanney L.B., Inman W.H., McCadden M.E., Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Trelat, and multiple acrochordons. A possible role for alpha-transforming growth factor in cutaneous paraneoplastic syndromes, N Engl J Med, 317, pp. 1582-1587, (1987)
[10] Benn J.J., Firth R.G., Sonksen P.H., Metabolic effects of an insulin-like factor causing hypoglycaemia in a patient with a haemangiopericytoma, Clin Endocrinol (Oxf), 32, pp. 769-780, (1990)

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