Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia

被引：0
作者：
Yan Li
Qingyu Xu
Na Lv
Lili Wang
Hongmei Zhao
Xiuli Wang
Jing Guo
Chongjian Chen
Yonghui Li
Li Yu
机构：
[1] Chinese PLA General Hospital,Department of Hematology and BMT center
[2] Department of Hematology,undefined
[3] Hainan Branch of Chinese PLA General Hospital,undefined
[4] Medical school of Nankai University,undefined
[5] Annoroad Gene Technology Co. Ltd,undefined
来源：
Journal of Hematology & Oncology | / 10卷
关键词：
Acute myeloid leukemia; DNA methylation; Clinical implications;
D O I：
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中图分类号：
学科分类号：
摘要：
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogeneous malignancy characterized by distinct genetic and epigenetic abnormalities. Recent genome-wide DNA methylation studies have highlighted an important role of dysregulated methylation signature in AML from biological and clinical standpoint. In this review, we will outline the recent advances in the methylome study of AML and overview the impacts of DNA methylation on AML diagnosis, treatment, and prognosis.
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