The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)—a systematic review

被引：35
作者：
Sigrun Ruth Hofmann
Franz Kapplusch
Katrin Mäbert
Christian Michael Hedrich
机构：
[1] Technische Universität Dresden,Pediatric Rheumatology and Immunology, Children’s Hospital Dresden, Faculty of Medicine Carl Gustav Carus
[2] University of Liverpool,Department of Women’s & Children’s Health, Institute of Translational Medicine
[3] Alder Hey Children’s NHS Foundation Trust Hospital,Department of Paediatric Rheumatology
来源：
Molecular and Cellular Pediatrics | / 4卷 / 1期
关键词：
Chronic non-bacterial osteomyelitis; CNO; Chronic recurrent multifocal osteomyelitis; CRMO; Inflammation; Cytokine; Mechanism;
D O I：
10.1186/s40348-017-0073-y
中图分类号：
学科分类号：
摘要：
Chronic non-bacterial osteomyelitis (CNO) belongs to the growing spectrum of autoinflammatory diseases and primarily affects the skeletal system. Peak onset ranges between 7 and 12 years of age. The clinical spectrum of CNO covers sometimes asymptomatic inflammation of single bones at the one end and chronically active or recurrent multifocal osteitis at the other.
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