The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)—a systematic review

被引：37
作者：
Sigrun Ruth Hofmann
Franz Kapplusch
Katrin Mäbert
Christian Michael Hedrich
机构：
[1] Pediatric Rheumatology and Immunology, Children’s Hospital Dresden, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, Dresden
[2] Department of Women’s & Children’s Health, Institute of Translational Medicine, University of Liverpool, Liverpool
[3] Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust Hospital, Liverpool
来源：
Molecular and Cellular Pediatrics | / 4卷 / 1期
关键词：
Chronic non-bacterial osteomyelitis; Chronic recurrent multifocal osteomyelitis; CNO; CRMO; Cytokine; Inflammation; Mechanism;
D O I：
10.1186/s40348-017-0073-y
中图分类号：
学科分类号：
摘要：
Chronic non-bacterial osteomyelitis (CNO) belongs to the growing spectrum of autoinflammatory diseases and primarily affects the skeletal system. Peak onset ranges between 7 and 12 years of age. The clinical spectrum of CNO covers sometimes asymptomatic inflammation of single bones at the one end and chronically active or recurrent multifocal osteitis at the other. Despite the intense scientific efforts, the exact molecular mechanisms of CNO remain unknown. Recent data suggest CNO as a genetically complex disorder with dysregulated TLR4/MAPK/inflammasome signaling cascades resulting in an imbalance between pro- and anti-inflammatory cytokine expression, leading to osteoclast activation and osteolytic lesions. In this manuscript, the current understanding of molecular patho-mechanisms in CNO will be discussed. © 2017, The Author(s).
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