Immunotherapy: Current Status and Future Perspectives

被引：0
|
作者：
Charalampos S. Floudas
Gagandeep Brar
Tim F. Greten
机构：
[1] National Institutes of Health,Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute
[2] National Institutes of Health,Liver Cancer Program, Center for Cancer Research, National Cancer Institute
来源：
Digestive Diseases and Sciences | 2019年 / 64卷
关键词：
Hepatocellular carcinoma; Immunotherapy; CTLA-4 antigen; Programmed cell death 1 receptor; B7-H1 antigen; Adoptive cellular immunotherapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hepatocellular carcinoma (HCC) has an increasing incidence and dismal prognosis, with few systemic treatments approved, including several small molecule tyrosine kinase inhibitors. The application of immune checkpoint inhibitors (ICIs) to HCC has resulted in durable activity, and further evaluation is ongoing. In this review, we discuss the immunologic principles and the mechanism of action of the ICIs and present the relevant clinical data. Furthermore, we provide an overview of the current and emerging immunotherapeutic approaches for HCC, such as combination treatments, vaccines, and cellular therapies.
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页码：1030 / 1040
页数：10
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