Inference to the best manipulation - A case study of qualitative reasoning in neuropharmacy

被引：0
作者：
Van Den Bosch A.P.M. [1 ]
机构：
[1] Department of Philosophy, Groningen University, 9718 CW, Groningen
来源：
Foundations of Science | 1999年 / 4卷 / 4期
关键词：
Discovery; Drug lead; Pharmacy; Philosophy of medicine; Qualitative reasoning;
D O I：
10.1023/A:1009652019363
中图分类号：
学科分类号：
摘要：
How can new drug lead suggestions be inferred from neurophysiological models? This paper addresses this question based on a case study of research into Parkinson's disease at the Groningen University Department of Pharmacy. It is argued that neurophysiological box-and-arrow models can be understood as qualitative differential equation models. An inference task is defined to help understand and possibly aid the discovery and explanation of new drug lead suggestions. © 2000 Kluwer Academic Publishers.
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收藏
页码：483 / 495
页数：12
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共 15 条
  • [1] De Jong H., Rip A., The Computer Revolution in Science: Steps Toward the Realization of Computer-supported Discovery Environments, Artificial Intelligence, 91, pp. 225-256, (1997)
  • [2] De Jong H., Mars N.J.I., Van Der Vet P.E., Computer-supported Analysis of Measurements in Materials Science, Foundation of Science, THIS ISSUE, (1999)
  • [3] Dunbar K., How Scientists Really Reason: Scientific Reasoning in Real-World Laboratories, The Nature of Insight, pp. 365-395, (1995)
  • [4] Karp P., Riley M., Representations of Metabolic Knowledge, Proceedings of the First International Conference on Intelligent Systems for Molecular Biology, pp. 207-215, (1993)
  • [5] Kuipers B., Qualitative Reasoning, Modeling and Simulation with Incomplete Knowledge, (1994)
  • [6] Kuipers Th.A.F., Vos R., Sie H., Design Research Programs and the Logic of their Development, Erkenntnis, 37, pp. 37-63, (1992)
  • [7] Kuipers Th.A.F., Abduction Aiming at Truth Approximation, Foundations of Science. Foundations of Science, 4, 3, pp. 307-323, (1999)
  • [8] Parent A., Cicchetti F., The Current Model of Basal Ganglia Organization under Scrutiny, Movement Disorders, 13, 2, pp. 199-202, (1998)
  • [9] Swanson D.R., Smalheiser N.R., An Interactive System for Finding Complementary Literatures: A Stimulus to Scientific Discovery, 91, pp. 183-203, (1997)
  • [10] Timmerman W., Dopaminergic Receptor Agents and the Basal Ganglia: Pharmacological Properties and Interactions with the GABA-ergic System, (1992)
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