Exposure to Low Level of Arsenic and Lead in Drinking Water from Antofagasta City Induces Gender Differences in Glucose Homeostasis in Rats

被引:0
作者
Javier Palacios
Domingo Roman
Fredi Cifuentes
机构
[1] Universidad Católica del Norte,Departamento de Química
[2] Universidad de Antofagasta,Laboratorio de Química Bio
[3] Universidad de Antofagasta,Inorgánica y Analítica Ambiental, Departamento de Química
来源
Biological Trace Element Research | 2012年 / 148卷
关键词
Gender differences; Arsenic; Lead; Drinking water; Insulin resistance; Rat;
D O I
暂无
中图分类号
学科分类号
摘要
Populations chronically exposed to arsenic in drinking water often have increased prevalence of diabetes mellitus. The purpose of this study was to compare the glucose homeostasis of male and female rats exposed to low levels of heavy metals in drinking water. Treated groups were Sprague–Dawley male and female rats exposed to drinking water from Antofagasta city, with total arsenic of 30 ppb and lead of 53 ppb for 3 months; control groups were exposed to purified water by reverse osmosis. The two treated groups in both males and females showed arsenic and lead in the hair of rats. The δ-aminolevulinic acid dehydratase was used as a sensitive biomarker of arsenic toxicity and lead. The activity of δ-aminolevulinic acid dehydratase was reduced only in treated male rats, compared to the control group. Treated males showed a significantly sustained increase in blood glucose and plasma insulin levels during oral glucose tolerance test compared to control group. The oral glucose tolerance test and the homeostasis model assessment of insulin resistance demonstrated that male rats were insulin resistant, and females remained sensitive to insulin after treatment. The total cholesterol and LDL cholesterol increased in treated male rats vs. the control, and triglyceride increased in treated female rats vs. the control. The activity of intestinal Na+/glucose cotransporter in male rats increased compared to female rats, suggesting a significant increase in intestinal glucose absorption. The findings indicate that exposure to low levels of arsenic and lead in drinking water could cause gender differences in insulin resistance.
引用
收藏
页码:224 / 231
页数:7
相关论文
共 215 条
[1]  
Carrasco EP(2004)Prevalence of type 2 diabetes and obesity in two Chilean aboriginal populations living in urban zones Rev Med Chil 132 1189-1197
[2]  
Perez FB(1998)Diabetes mellitus associated with arsenic exposure in Bangladesh Am J Epidemiol 148 198-203
[3]  
Angel BB(2007)Inorganic arsenic exposure and type 2 diabetes mellitus in Mexico Environ Res 104 383-389
[4]  
Albala CB(1994)Ingested inorganic arsenic and prevalence of diabetes mellitus Am J Epidemiol 139 484-492
[5]  
Santos JL(2006)Lead toxicity, a review of the literature. Part 1: exposure, evaluation, and treatment Altern Med Rev 11 2-22
[6]  
Larenas GY(2007)Chronic ingestion of arsenic (< 40 mu M) in tap water impairs vascular endothelium response in aorta of female rats Clin Exp Hypertens 29 98–98-541
[7]  
Montalvo DV(2009)Chronic exposure to arsenic in tap water reduces acetylcholine-induced relaxation in the aorta and increases oxidative stress in female rats Int J Toxicol 28 534-232
[8]  
Rahman M(2000)Severe exposure to environmental lead in a child population in Antofagasta, Chile Rev Med Chil 128 221-95
[9]  
Tondel M(2000)Total arsenic, lead, cadmium, copper, and zinc in some salt rivers in the northern Andes of Antofagasta, Chile Sci Total Environ 255 85-433
[10]  
Ahmad SA(2004)Inhibition of insulin-dependent glucose uptake by trivalent arsenicals: possible mechanism of arsenic-induced diabetes Toxicol Appl Pharmacol 198 424-1109