Involvement of P-Glycoprotein in the Transport of Saquinavir and Indinavir in Rat Brain Microvessel Endothelial and Microglia Cell Lines

被引：0
作者：
Patrick T. Ronaldson
Gloria Lee
Shannon Dallas
Reina Bendayan
机构：
[1] University of Toronto,Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy
来源：
Pharmaceutical Research | 2004年 / 21卷
关键词：
central nervous system; drug transport; indinavir; P-glycoprotein; saquinavir;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. Membrane-bound efflux transporters, such as P-glycoprotein (P-gp), may limit the brain entry and distribution of HIV-1 protease inhibitors and be in part responsible for HIV-1-associated dementia treatment failure. The purpose of this study was to characterize the transport properties of saquinavir and indinavir in a brain microvessel endothelial cell line and in microglia, the immune cells of the brain and primary HIV-1 cellular target.
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页码：811 / 818
页数：7
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