Renal tubular dysfunction in epileptic children on valproic acid therapy

被引：0

作者：

S. Altunbas¸ak

Dinçer Yıldız

A. Anarat

H. Refik Burgut

机构：

[1] Department of Pediatric Neurology,

[2] Çukurova University Medical Faculty,undefined

[3] 01330 Balcali-Adana,undefined

[4] Turkey e-mail: sakira@mail.cu.edu.tr Tel.: +90-322-3386936,undefined

[5] Fax: +90-322-3386572,undefined

[6] Resident in Pediatrics,undefined

[7] Çukurova University Medical Faculty,undefined

[8] Adana,undefined

[9] Turkey,undefined

[10] Department of Pediatric Nephrology,undefined

[11] Çukurova University Medical Faculty,undefined

[12] Adana,undefined

[13] Turkey,undefined

[14] Department of Biostatistics,undefined

[15] Çukurova University Medical Faculty,undefined

[16] Adana,undefined

[17] Turkey,undefined

来源：

Pediatric Nephrology | 2001年 / 16卷

关键词：

Keywords Valproic acid; Renal tubular function; β2-Microglobulin; N-Acetyl-β-d-glucosamine; Malondialdehyde;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

To investigate the effects of valproic acid (VPA) on renal tubular function, we examined 15 ambulatory children with epilepsy who received VPA for at least 6 months. None of the patients had mental retardation. Fourteen age- and sex-matched children were used as a control group. No statistically significant differences were found between patients and control subjects with respect to blood urea nitrogen (BUN), creatinine (Cr), uric acid, creatinine clearance (Ccr), tubular reabsorption of phosphorus (TRP), urinary Ca:creatinine ratio, urinary pH and mean urinary β2-microglobulin concentrations (P>0.05). Protein and glucose in patient urine samples were negative. Urine microscopic examinations and amino acid chromatographies of patients were also normal. However, significant differences were found between patient and control groups with respect to mean urinary N-acetyl-beta-d-glucosamine:creatinine ratio (NAG:Cr) and mean urinary malondialdehyde:creatinine (MDA:Cr) ratio (P<0.05). In conclusion, ambulatory children with epilepsy taking VPA therapy may develop proximal renal tubular dysfunction. Although this finding is clini-cally insignificant, it should be kept in mind during VPA therapy.

引用

页码：256 / 259

页数：3