Prevalence of human papillomavirus infection and genotype distribution among high-risk Korean women for prospecting the strategy of vaccine development

被引：0
作者：
Jee Eun Rhee
Mi Yeong Shin
Choong Mo Kim
Hye Young Kee
Jae Keun Chung
Sang-Kee Min
Seong-Joon Kim
Dai-Ho Jang
Sung Soon Kim
Byeong-Sun Choi
机构：
[1] National Institute of Health,Division of AIDS, Center for Immunology and Pathology
[2] Korea Centers for Disease Control and Prevention,Division of Microbiology
[3] Jeollanam-Do Institute of Health and Environment,Department of Health Research
[4] Gwangju Institute of Health and Environment,Division of Epidemiology
[5] Busan Institute of Health and Environment,undefined
来源：
Virology Journal | / 7卷
关键词：
Cervical Cancer; Invasive Cervical Cancer; Korean Woman; Precancerous Cervical Lesion; South Korean Woman;
D O I：
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摘要：
We investigated the prevalence of human papillomavirus (HPV) infection and the distribution of high-risk HPV genotypes among 2,308 high-risk Korean women to predict how much the current prophylactic HPV vaccines might affect the prevention of cervical cancer in Korea. HPV DNA was detected in 939 women (40.7%) but only one-third of women were positive for HPV-16 and/or HPV-18, the genotypes used for developing the HPV vaccines. Thus, the development of area-specific HPV vaccines based on dominant HPV genotypes in our country is needed for preventing HPV infection and the development of premalignant lesions in the cervix of Korean women.
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