Hepatoprotective and anti-inflammatory potential of chebulagic acid on carbon tetrachloride–induced hepatic fibrosis by antioxidative activities in rats

被引：2

作者：

Sundaram R. ^{[1
,2
]}

Ganesh V. ^{[1
]}

Nandhakumar E. ^{[3
]}

Muthu K. ^{[3
]}

机构：

[1] Dental Campus, Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Deemed To Be University, West K.K. Nagar, Chennai, 600078, Tamil Nadu

[2] Department of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Vellapanchavadi, Chennai

[3] Department of Biochemistry, Sri Muthukumaran Medical College Hospital and Research Institute (Tamil Nadu Dr, MGR Medical University), Chikkarayapuram, Chennai

[4] Department of Chemistry, Manomaniam Sundaranar University, Tirunelveli, 627012, Tamil Nadu

来源：

Comparative Clinical Pathology | 2021年 / 30卷 / 6期

关键词：

Antioxidant; CCL4; Chebulagic acid; Inflammation; Liver fibrosis;

D O I：

10.1007/s00580-021-03295-0

中图分类号：

学科分类号：

摘要：

The aim of the present study was to evaluate the hepatoprotective, antioxidant, and anti-inflammatory potential of chebulagic acid on carbon tetrachloride–induced hepatic fibrosis in rats. The liver was damaged in the rats using CCL4 (2 ml/kg b.w dissolved in 20% corn oil) intragastrically twice/week for 8 weeks. After 8 weeks, activities of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and lactate dehydrogenase, lipid peroxidation markers, and enzymic and non-enzymic antioxidant enzymes, inflammatory and anti-inflammatory cytokines were analyzed and all these parameters were altered. Chebulagic acid administration reversed all the altered parameters to near-normal levels. Improved histological and immunohistochemical observations liver supported the biochemical investigated. Hence, chebulagic acid exhibits hepatoprotective effects against CCl4-induced liver damage. © 2021, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.

引用

页码：961 / 971

页数：10

共 31 条

[1]

Baker H., Frank O., Angelis B., Feingold S., Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol, Nutr Rep Int, 21, pp. 531-536, (1980)

[2]

Jalali Ghassam B., Ghaffari H., Prakash H.S., Kini K.R., Antioxidant and hepatoprotective effects of Solanum xanthocarpum leaf extracts against CCl4-induced liver injury in rats, Pharm Biol, 52, 8, pp. 1060-1068, (2014)

[3]

Chen X., Ying X., Zhang W., Chen Y., Shi C., Hou Y., Zhang Y., The hepatoprotective effect of fraxetin on carbon tetrachloride induced hepatic fibrosis by antioxidative activities in rats, Int Immunopharmacol, 17, pp. 543-547, (2013)

[4]

Elgawish R.A.R., Rahman H.G.A., Abdelrazek H.M.A., Green tea extract attenuates CCl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis, Toxicol Rep, 2, pp. 1149-1156, (2015)

[5]

Ellman G.L., Tissue sulfhydryl groups, Arch Biochem Biophys, 82, pp. 70-77, (1959)

[6]

Frei B., Higdon J.V., Antioxidant activity of tea polyphenols in vivo: evidence from animal studies, J Nutr, 133, 10, pp. 3275-3284, (2003)

[7]

Fu Y., Zheng S., Lin J., Ryerse J., Chen A., Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation, Mol Pharmacol, 73, pp. 399-409, (2008)

[8]

Gao H., Huang Y.N., Xu P., Kawabata Y.J., Inhibitory effect on a-glucosidase by the fruits of Terminalia chebula Retz, Food Chem, 105, pp. 628-634, (2007)

[9]

Ghatak S., Biswas A., Dhali G.K., Chowdhury A., Boyer J.L., Santra A., Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis inmice, Toxicol Appl Pharmacol, 251, pp. 59-69, (2011)

[10]

Habig W.H., Pabst M.J., Jakoby W.B., Glutathione-S-transferase: the first step in mercapturic acid formation, J Biol Chem, 249, pp. 7130-7139, (1974)

← 1 2 3 4 →