The nucleosome map of the mammalian liver

被引：0
作者：
Zhaoyu Li
Jonathan Schug
Geetu Tuteja
Peter White
Klaus H Kaestner
机构：
[1] School of Medicine,Department of Genetics
[2] University of Pennsylvania,undefined
[3] Institute of Diabetes,undefined
[4] Obesity and Metabolism,undefined
[5] School of Medicine,undefined
[6] University of Pennsylvania,undefined
来源：
Nature Structural & Molecular Biology | 2011年 / 18卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Pioneer transcription factors such as Foxa1 and Foxa2 need to bind to nucleosomal DNA to regulate chromatin structure and gene activation. Now a genome-wide nucleosome mapping in mouse liver shows that the maintenance of nucleosome position and chromatin structure surrounding Foxa23 binding sites is independent of Foxa1/2.
引用
收藏
页码：742 / 746
页数：4
相关论文
共 77 条
[1]  
Schones DE(2008)Dynamic regulation of nucleosome positioning in the human genome Cell 132 887-898
[2]  
Shivaswamy S(2008)Dynamic remodeling of individual nucleosomes across a eukaryotic genome in response to transcriptional perturbation PLoS Biol. 6 e65-1063
[3]  
Valouev A(2008)A high-resolution, nucleosome position map of Genome Res. 18 1051-3563
[4]  
Beato M(1997) reveals a lack of universal sequence-dictated positioning Nucleic Acids Res. 25 3559-398
[5]  
Eisfeld K(1993)Transcription factor access to chromatin Cell 75 387-390
[6]  
McPherson CE(1994)An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array EMBO J. 13 380-7763
[7]  
Shim EY(1994)A histone-binding protein, nucleoplasmin, stimulates transcription factor binding to nucleosomes and factor-induced nucleosome disassembly J. Biol. Chem. 269 7756-4251
[8]  
Friedman DS(1998)Nucleosome binding by the constitutive transcription factor Sp1 Mol. Cell. Biol. 18 4245-42817
[9]  
Zaret KS(2001)Targeted disruption of the gene encoding hepatocyte nuclear factor 3γ results in reduced transcription of hepatocyte-specific genes J. Biol. Chem. 276 42812-947
[10]  
Chen H(2005) (hepatocyte nuclear factor 3γ) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast Nature 435 944-1545
12345678