Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth

被引：0
作者：
V Fritz
Z Benfodda
C Henriquet
S Hure
J-P Cristol
F Michel
M-A Carbonneau
F Casas
L Fajas
机构：
[1] IGMM,Department of Physiology
[2] CNRS,undefined
[3] Institut de Génétique Moléculaire de Montpellier,undefined
[4] CNRS,undefined
[5] UMR5535,undefined
[6] Université de Montpellier 2,undefined
[7] IBMM,undefined
[8] Institut des Biomolécules Max Mousseron CNRS UMR5247 CC 1706,undefined
[9] Laboratoire des Acides Aminés,undefined
[10] Peptides et Protéines – Université de Montpellier 2,undefined
[11] Laboratoire de Chimie Bioorganique,undefined
[12] Université de Nîmes,undefined
[13] IRCM,undefined
[14] Institut de Recherche en Cancérologie de Montpellier,undefined
[15] Laboratoire de Biochimie,undefined
[16] Centre Hospitalier Universitaire Lapeyronie,undefined
[17] UMR 204 Prévention des Malnutritions et des Pathologies Associées,undefined
[18] Institut Universitaire de Recherche Clinique,undefined
[19] UMR 204 NUTRIPASS,undefined
[20] Institut Universitaire des Recherches Cliniques,undefined
[21] INRA UMR 0866,undefined
[22] Centre Hospitalier Régional Universitaire de Montpellier,undefined
[23] Université de Lausanne,undefined
来源：
Oncogene | 2013年 / 32卷
关键词：
lipids; cancer; FAS; metabolism; prostate;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
One of the most conserved features of all cancers is a profound reprogramming of cellular metabolism, favoring biosynthetic processes and limiting catalytic processes. With the acquired knowledge of some of these important changes, we have designed a combination therapy in order to force cancer cells to use a particular metabolic pathway that ultimately results in the accumulation of toxic products. This innovative approach consists of blocking lipid synthesis, at the same time that we force the cell, through the inhibition of AMP-activated kinase, to accumulate toxic intermediates, such as malonyl-coenzyme A (malonyl-CoA) or nicotinamide adenine dinucleotide phosphate. This results in excess of oxidative stress and cancer cell death. Our new therapeutic strategy, based on the manipulation of metabolic pathways, will certainly set up the basis for new upcoming studies defining a new paradigm of cancer treatment.
引用
收藏
页码：5101 / 5110
页数：9
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