Reduction of non-esterified fatty acids improves insulin sensitivity and lowers oxidative stress, but fails to restore oxidative capacity in type 2 diabetes: a randomised clinical trial

[1] Petersen KF(2004)Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes N Engl J Med 350 664-671

[2] Dufour S(2010)Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals Diabetologia 53 1714-1721

[3] Befroy D(2008)Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients Diabetes 57 2943-2949

[4] Garcia R(2007)Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects Diabetologia 50 113-120

[5] Shulman GI(2008)Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes Diabetes Care 31 1644-1649

[6] Phielix E(2008)Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction Eur J Endocrinol 158 643-653

[7] Meex R(2007)Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes PLoS Med 4 e154-199

[8] Moonen-Kornips E(2005)Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents PLoS Med 2 e233-140

[9] Hesselink MK(2011)Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes J Intern Med 269 189-3319

[10] Schrauwen P(2006)Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle Diabetes 55 136-8001

[1] Petersen KF(2004)Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes N Engl J Med 350 664-671

[2] Dufour S(2010)Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals Diabetologia 53 1714-1721

[3] Befroy D(2008)Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients Diabetes 57 2943-2949

[4] Garcia R(2007)Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects Diabetologia 50 113-120

[5] Shulman GI(2008)Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes Diabetes Care 31 1644-1649

[6] Phielix E(2008)Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction Eur J Endocrinol 158 643-653

[7] Meex R(2007)Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes PLoS Med 4 e154-199

[8] Moonen-Kornips E(2005)Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents PLoS Med 2 e233-140

[9] Hesselink MK(2011)Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes J Intern Med 269 189-3319

[10] Schrauwen P(2006)Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle Diabetes 55 136-8001