Spreading depression as a preclinical model of migraine

被引：0
作者：
Andrea M. Harriott
Tsubasa Takizawa
David Y. Chung
Shih-Pin Chen
机构：
[1] Massachusetts General Hospital,Neurovascular Research Lab, Department of Radiology
[2] Massachusetts General Hospital,Department of Neurology
[3] Keio University School of Medicine,Department of Neurology
[4] National Yang-Ming University,Institute of Clinical Medicine
[5] National Yang-Ming University,Brain Research Center
[6] Taipei Veterans General Hospital,Division of Translational Research, Department of Medical Research
[7] Neurological Institute,Department of Neurology
[8] Taipei Veterans General Hospital,undefined
来源：
The Journal of Headache and Pain | 2019年 / 20卷
关键词：
Migraine; Aura; Spreading depression; Optogenetics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Spreading depression (SD) is a slowly propagating wave of near-complete depolarization of neurons and glial cells across the cortex. SD is thought to contribute to the underlying pathophysiology of migraine aura, and possibly also an intrinsic brain activity causing migraine headache. Experimental models of SD have recapitulated multiple migraine-related phenomena and are considered highly translational. In this review, we summarize conventional and novel methods to trigger SD, with specific focus on optogenetic methods. We outline physiological triggers that might affect SD susceptibility, review a multitude of physiological, biochemical, and behavioral consequences of SD, and elaborate their relevance to migraine pathophysiology. The possibility of constructing a recurrent episodic or chronic migraine model using SD is also discussed.
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