Long-Term Effects of Prenatal Stress on the Characteristics of Hippocampal Neurons in Rats with Different Excitability of the Nervous Systems
被引:0
作者:
N. A. Dyuzhikova
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机构:I. P. Pavlov Institute of Physiology,Laboratory of Higher Nervous Activity Genetics
N. A. Dyuzhikova
N. V. Shiryaeva
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机构:I. P. Pavlov Institute of Physiology,Laboratory of Higher Nervous Activity Genetics
N. V. Shiryaeva
M. B. Pavlova
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机构:I. P. Pavlov Institute of Physiology,Laboratory of Higher Nervous Activity Genetics
M. B. Pavlova
A. I. Vaido
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机构:I. P. Pavlov Institute of Physiology,Laboratory of Higher Nervous Activity Genetics
A. I. Vaido
机构:
[1] I. P. Pavlov Institute of Physiology,Laboratory of Higher Nervous Activity Genetics
[2] Russian Academy of Sciences,undefined
来源:
Bulletin of Experimental Biology and Medicine
|
2012年
/
152卷
关键词:
prenatal stress;
hippocampus;
density of neurons;
heterochromatin;
highly excitable and low excitable rat strains;
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摘要:
We studied the effects of prenatal emotional painful stress on numerical density of neurons and characteristics of heterochromatin in developing and mature hippocampus of rats with different excitability of the nervous systems. It was shown that prenatal stress reduces the numerical density of neurons in hippocampal CA3 fi eld in 24-day-old and adult (3 months) low excitable animals and chromocenter area in cells of developing hippocampus in embryos of both strains. The difference in chromocenter areas in offspring of stressed females was retained on postnatal day 24.