Organ Preservation in Rectal Cancer

被引：0
作者：
Jonathan B. Yuval
Hannah M. Thompson
Julio Garcia-Aguilar
机构：
[1] Memorial Sloan Kettering Cancer Center,Department of Surgery
来源：
Journal of Gastrointestinal Surgery | 2020年 / 24卷
关键词：
Nonoperative management; Watch-and-wait; Rectal cancer; Organ preservation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A proportion of patients with rectal cancer who undergo neoadjuvant treatment end up with a complete pathological response. Because these patients have excellent oncological outcomes, many have questioned if surgical treatment in this population constitutes overtreatment. There is growing interest in watch and wait with selective organ preservation for rectal cancer patients. We review the fundamentals and key considerations of this approach including patient selection, available treatment regimens, assessment of response, long-term monitoring of response, and long-term oncological and functional outcomes.
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页码：1880 / 1888
页数：8
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共 313 条
  • [1] Sauer R(2004)Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med. 351 1731-40
  • [2] Becker H(2010)Colorectal cancer Lancet. 375 1030-47
  • [3] Hohenberger W(2011)Patient-reported outcomes after neoadjuvant chemoradiotherapy for rectal cancer: a multicenter prospective observational study Ann Surg. 253 71-7
  • [4] Rodel C(2015)Bowel function 14 years after preoperative short-course radiotherapy and total mesorectal excision for rectal cancer: report of a multicenter randomized trial Clin Colorectal Cancer. 14 106-14
  • [5] Wittekind C(2015)Organ preservation in rectal adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemotherapy, and total mesorectal excision or nonoperative management BMC Cancer. 15 767-44
  • [6] Fietkau R(2010)Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data Lancet Oncol. 11 835-91
  • [7] Cunningham D(2012)A phase II trial of neoadjuvant chemoradiation and local excision for T2N0 rectal cancer: preliminary results of the ACOSOG Z6041 trial Ann Surg Oncol. 19 384-66
  • [8] Atkin W(2015)Effect of adding mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal cancer: a multicentre, phase 2 trial Lancet Oncol. 16 957-6
  • [9] Lenz HJ(2012)Neoadjuvant treatment response as an early response indicator for patients with rectal cancer J Clin Oncol. 30 1770-14
  • [10] Lynch HT(1920)Treatment of cancer, particularly of the tongue, tonsil and rectum, by buried emanation Am J Roentgenol. 7 92-7
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