Relationship between clinical course and Diffusion-weighted MRI findings in sporadic Creutzfeldt-Jakob Disease

被引：0
作者：
Sang-Hun Yi
Key-Chung Park
Sung-Sang Yoon
Eui-Jong Kim
Won-Chul Shin
机构：
[1] Kyung Hee University School of Medicine,Department of Neurology Kyung Hee Medical Center
[2] Kyung Hee University School of Medicine,Department of Diagnostic Radiology
[3] Kyung Hee University East-West Neo Medical Center,Department of Neurology
来源：
Neurological Sciences | 2008年 / 29卷
关键词：
Clinical course; Clinical manifestations; Cortical hyperintensity; Cortical plus basal ganglia hyperintensity; Diffusion-weighted MRI; Sporadic CJD;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aim of this study was to investigate the relationship between clinical course and diffusion-weighted MRI (DWI) findings in sporadic Creutzfeldt-Jakob Disease (sCJD). We reviewed clinical records and MRI examination in nine probable sCJD. According to hyperintense signal distribution on DWI, the patients were classified into two groups with cortical ribbon plus basal ganglia hyperintensity (6/9) and with only increased cortical signals (3/9). Clinical features including quadriparesis (3/6), akinetic mutism (2/6), and dysphasia (2/6), which were usually observed in the more advanced stage of CJD, were noted only in patients with cortical ribbon plus basal ganglia hyperintensity at the time of initial DWI examination. The patients with the cortical plus basal ganglia hyperintensity (6.4±1.7 weeks) had a shorter interval from symptom onset to akinetic mutism than those with only cortical ribbon hyperintensity (26.0±22.5 weeks) (p=0.02). These findings suggest that DWI may predict the clinical course of CJD.
引用
收藏
页码：251 / 255
页数：4
相关论文
共 62 条
  • [1] Meissner B.(2004)Sporadic Creutzfeldt-Jakob disease: magnetic resonance imaging and clinical findings Neurology 63 450-456
  • [2] Kortner K.(2005)Clinical course in young patients with sporadic Creutzfeldt-Jakob disease Ann Neurol 58 533-543
  • [3] Bartl M.(2007)Chronological changes in MRI and CSF biochemical markers in Creutzfeldt-Jakob disease patients Dement Geriatr Cogn Disord 23 372-381
  • [4] Boesenberg C.(1980)Serial EEG findings in 27 cases of Creutzfeldt-Jakob disease Arch Neurol 37 143-145
  • [5] Schulz-Schaeffer W.J.(1996)The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies N Engl J Med 335 924-930
  • [6] Meissner B.(2004)Diffusion-weighted MRI abnormalities as an early diagnostic marker for Creutzfeldt-Jakob disease Neurology 63 443-449
  • [7] Satoh K.(2005)Diffusion-weighted and fluid-attenuated inversion recovery imaging in Creutzfeldt-Jakob disease: high sensitivity and specificity for diagnosis AJNR Am J Neuroradiol 26 1551-1562
  • [8] Shirabe S.(1998)MRI in sporadic Creutzfeldt-Jakob disease: correlation with clinical and neuropathological data Neuroradiology 40 65-70
  • [9] Eguchi H.(1999)Abnormal diffusion-weighted magnetic resonance images in Creutzfeldt-Jakob disease Arch Neurol 56 577-583
  • [10] Chiofalo N.(2000)Diffusion-weighted MRI in patients with Creutzfeldt-Jakob disease Nervenarzt 71 91-95
1234567