TNF-α in the serum and synovial fluid of patients with rheumatoid arthritis: correlation with sonographic parameters: a cross-sectional study

被引:1
作者
El Hassany, Aya [1 ]
Tharwat, Samar [1 ,2 ]
Mansour, Mostafa [3 ]
Enein, Asmaa Farouk [1 ]
机构
[1] Mansoura Univ Hosp, Fac Med, Dept Internal Med, Rheumatol & Immunol Unit, El Gomhouria St, Mansoura, Dakahlia, Egypt
[2] Horus Univ, Fac Med, Dept Internal Med, New Damietta, Egypt
[3] Mansoura Univ Hosp, Fac Med, Dept Clin Pathol, El Gomhouria St, Mansoura, Dakahlia, Egypt
关键词
TNF-alpha; Rheumatoid arthritis; Musculoskeletal ultrasound; Knee effusion; NECROSIS-FACTOR-ALPHA; DISEASE-ACTIVITY; CYTOKINES; VALIDATION; CRITERIA; MARKERS;
D O I
10.1186/s43166-024-00256-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Rheumatoid arthritis (RA) is a chronic, inflammatory joint condition characterized by overproduction of pro-inflammatory cytokines. We aimed to assess TNF-alpha levels in both serum and synovial fluid in effusive knees in RA patients and find out if synovial fluid levels correlate with ultrasound (US)-detected local knee inflammatory and/or destructive changes in these patients. Results This study included 40 patients (20 with RA, 10 with systemic lupus erythematosus (SLE), and 10 with osteoarthritis (OA)) who had knee effusion (unilateral or bilateral) upon clinical examination. The mean age of RA patients was 48.4 years; most of them were females (80%), with a median (min-max) duration of knee effusion of 2 (1.5-3) months. Serum TNF-alpha was significantly higher in RA vs. non-RA and in OA cases (p = 0.052, 0.022, respectively), while in the synovial fluid, the difference was not statistically significant (3.73 +/- 0.72 vs. 3.48 +/- 0.58 U/ml, p = 0.252). Serum TNF-alpha at a cut point of > 3.24 U/ml can significantly discriminate RA from OA with 65% sensitivity and 90% specificity (AUC = 0.725, P = 0.018). There was no statistically significant correlation between synovial TNF-alpha and US parameters of the knee, either in RA or non-RA patients. Conclusions RA, OA, and SLE effusive joints share the presence of local articular joint inflammation, while systemic inflammation is more discriminative for RA patients regarding the level of TNF-alpha. The lack of correlation of TNF-alpha with ultrasonographic findings reflects the multifactorial complexity of these autoimmune diseases.
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页数:11
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